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Table 2 Characteristics of systematic reviews included in the Evidence Mapping 

From: Therapeutic use of cannabis and cannabinoids: an evidence mapping and appraisal of systematic reviews

Systematic review

Search date

Population

Included studies

Studies design

Number of patients

Meta-analysis

Tool for risk of bias assessment

RCT

NRCT

UCT

Obs

ABO 2017

November 2016

Neurogenic urinary tract dysfunction in multiple sclerosis (MS).

3

2

0

1

0

426

Yes

Cochrane Risk of Bias

ANDREAE 2015

April 2014

Chronic neuropathic pain

5

5

0

0

0

178

Yes

Cochrane Risk of Bias

BALDINGER 2012

February 2011

Amyotrophic lateral sclerosis/ motor neuron disease

1

1

0

0

0

22

No

Cochrane Risk of Bias

BEGA 2014

April 2014

Parkinson Disease

2

2

0

0

0

26

No

American Academy of Neurology classification

BOYCHUCK 2015

April 2013

Chronic nonmalignant neuropathic pain

13

13

0

0

0

771

No

JADAD 5

CAMPELL 2001

October 1999

Pain.

8

6

0

0

2

222

No

JADAD 5

CURTIS 2009

October 2008

Gilles de la Tourette

2

2

0

0

0

28

No

CONSORT

DE SOUZA 2013

December 2012

Fibromyalgia

2

2

0

0

0

69

No

Jadad5, Cochrane

DESHPANDE 2015

April 2014

Chronic noncancer pain

6

6

0

0

0

226

No

JADAD 5

FINNERUP 2015

April 2013

Neuropathic pain

9

9

0

0

0

1310

Yes

JADAD 5

FITZCHARLES 2016a

April 2015

Fibromyalgia, back pain, osteoarthritis, rheumatoid arthritis

4

4

0

0

0

160

No

Cochrane Risk of Bias

FITZCHARLES 2016b

January 2015

Rheumatic diseases

4

4

0

0

0

201

No

Cochrane Risk of Bias

GLOSS 2014

September 2013

Epilepsy

4

4

0

0

0

48

No

Cochrane Risk of Bias

ISKEDIJAN 2006

June 2006

Neuropathic pain.

7

7

0

0

0

298

Yes

JADAD 5

JAWAHAR 2013

December 2012

Multiple sclerosis patients.

4

4

0

0

0

565

Yes

Cochrane Risk of Bias

KHAISER 2016

May /2016

Pain

11

9

0

1

1

420

No

Own criteria

KOPPEL 2014

November 2013

Several neurologic conditions

28

26

1

1

0

3567

No

American Academy of Neurology classification

KRISHNAN 2009

April 2008

Dementia

1

1

0

0

0

15

No

Cochrane Risk of Bias

LAKHAN 2009

April 2009

Multiple Sclerosis-related spasticity

6

6

0

0

0

481

No

JADAD 5

LANGHORST 2015

March 2014

Inflamatory Bowel Disease

1

1

0

0

0

22

No

Cochrane Risk of Bias

LUTGE 2013

July 2012

Patients infected with human immunodeficiency virus (HIV)

7

7

0

0

0

330

No

Cochrane Risk of Bias

LYNCH 2011

September–October 2010

Chronic pain

18

18

0

0

0

766

No

JADAD 7

LYNCH 2015

October 2014

Chronic pain

11

0

0

0

0

1185

No

JADAD 7

MACHADO 2008

December 2006

Cancer patients receiving chemotherapy

30

30

0

0

0

1719

Yes

JADAD

MARTIN 2009

February 2008

Chronic pain.

18

18

0

0

0

809

Yes

JADAD 5

MEHTA 2015

September 2015

Pain post spinal cord injury

2

2

0

0

0

29

No

PEDRO

MEYER 2010

2008

Acute phase of acquired brain injury

2

2

0

0

0

928

No

PEDRO

MÜCKE 2016

April 2015

Palliative medicine

9

9

0

0

0

1561

Yes

Cochrane Risk of Bias

OMS 2016

September 2016

Multiple sclerosis, chronic pain, HIV/AIDS, Dementia, Tourette syndrome and adults in chemotherapy.

43

43

0

0

0

4586

Yes

Cochrane Risk of Bias

OTERO-ROMERO 2016

August 2013

Multiple Sclerosis-related spasticity

8

8

0

0

0

 

No

EFNS scientific task forces

PETZKE 2016

November 2015

Neuropathic pain syndromes

15

15

0

0

0

1619

Yes

Cochrane Risk of Bias

PILLIPS 2010

February 2010

Neuropathic pain in HIV patients

2

2

0

0

0

89

Yes

JADAD 7

PILLIPS 2016

December 2014

Children and young people receiving chemotherapy

4

4

0

0

0

78

Yes

Cochrane Risk of Bias

RICHARDS 2012

December 2010

Pain in patients with rheumatoid arthritis

1

1

0

0

0

58

No

COChrane Risk of Bias

SHAKESPEARE 2003

June 2003

Multiple Sclerosis-related spasticity

2

2

0

0

0

40

No

Cochrane Risk of Bias

SMITH 2015

January 2015

Chemotherapy-induced nausea in cancer patients

23

23

0

0

0

1326

Yes

Cochrane Risk of Bias

SNEDECOR 2014

June 2011

Painful diabetic peripheral neuropathy

1

1

0

0

0

30

Yes

JADAD 5

STEVENS 2017

August 2016

Acute pain.

7

7

0

0

0

611

No

Cochrane Risk of Bias

TEASELL 2010

June 2009

Spinal Cord Injury

2

1

0

0

1

22

No

PEDRO, Downs and Black checklist

TRAMER 2001

August 2008

Sickness induced by chemotherapy

30

30

0

0

0

1366

Yes

JADAD 5

VAN DEN ELSEN 2014

October 2013

Older subjects.

5

5

0

0

0

267

No

Cochrane Risk of Bias

VOLZ 2016

March 2015

Inflammatory diseases, irritable bowel syndrome and chronic pancreatitis

1

1

0

0

0

21

No

Cochrane Risk of Bias

WANG 2008

October 2007

Safety of medical cannabis use.

31

23

0

0

8

3107

Yes

JADAD, Downs and Back checklist

WHITING 2015

April 2015

Chronic pain, spasticity, adults in chemotherapy, weight gain in HIV, sleep disorders, Tourette syndrome

79

79

0

0

0

6462

Yes

Cochrane Risk of Bias