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Table 4 Mean clinical chemistry parameters for 28 week repeated oral doses of E. kebericho decoction treated rats

From: Acute and sub-acute toxicity of Echinops kebericho decoction in rats

ParameterMaleFemaleP-value
control150 mg/kg300 mg/kg600 mg/kgControl150 mg/kg300 mg/kg600 mg/kg 
AST (U/L)260.2 ± 30.06288.3 ± 70.71241.6 ± 76.59173.5 ± 21.89304.2 ± 256.1190.6 ± 20.74193.6 ± 29.08301.6 ± 309.40.0559 /0.1173
ALT (U/L)84.20 ± 7.7380.75 ± 6.9988.00 ± 14.3764.20 ± 6.30123.0 ± 128.370.40 ± 4.8856.60 ± 7.1683.80 ± 22.110.0036 */0.6072
ALP (U/L)74.60 ± 20.2671.25 ± 23.91106.6 ± 56.20131.3 ± 16.88197.8 ± 126.452.20 ± 16.9845.40 ± 46.4183.20 ± 32.820.0162 */0.0577
Creatinine (mg/dl)0.60 ± 0.070.52 ± 0.100.52 ± 0.160.30 ± 0.120.60 ± 0.070.52 ± 0.080.46 ± 0.050.42 ± 0.110.0077 */0.0005 **
Urea (mg/dL)40.30 ± 2.9442.00 ± 1.2650.48 ± 6.5841.50 ± 3.9047.22 ± 6.1448.30 ± 7.9742.72 ± 5.0243.88 ± 3.510.1288/0.5085
Protein total (g/dl)5.90 ± 0.736.30 ± 0.746.32 ± 1.005.80 ± 0.637.06 ± 0.566.60 ± 1.406.48 ± 0.586.62 ± 0.430.1531 /0.9694
Albumin (g/dl)3.20 ± 0.123.22 ± 0.173.14 ± 0.213.05 ± 0.103.56 ± 0.243.36 ± 0.153.38 ± 0.223.42 ± 0.2280.0122*/0.6266
Glucose (mg/dl)127.4 ± 42.51178.8 ± 69.63181.6 ± 64.31124.8 ± 33.04116.2 ± 17.71193.0 ± 45.67140.0 ± 31.16188.6 ± 62.420.0457*/0.0581
Bil-total (mg/dl)0.18 ± 0.040.38 ± 0.150.20 ± 0.00.28 ± 0.100.26 ± 0.050.16 ± 0.050.24 ± 0.090.34 ± 0.050.0036*/0.0644
Bil-direct (mg/dl)0.10 ± 0.00.32 ± 0.100.14 ± 0.060.12 ± 0.050.14 ± 0.060.20 ± 0.070.14 ± 0.060.22 ± 0.110.0129*/0.0065**
TG (mg/dl)79.40 ± 20.1979.50 ± 8.9666.60 ± 20.1951.25 ± 13.4598.00 ± 41.4375.20 ± 14.4558.00 ± 17.5662.00 ± 9.380.0338*/0.0042**
Cholesterol (mg/dl)33.60 ± 10.8579.50 ± 16.7665.60 ± 15.6338.50 ± 3.7084.60 ± 37.6381.80 ± 29.7881.20 ± 18.1080.60 ± 12.520.0013*/0.2970
  1. *Significant p-value when males and females are treated separately, **Significant p-value when males and females are grouped together: Where, ALP Alkaline phosphatase, ALT Alanine aminotransferase, AST Aspartate Aminotransferase, TG Triglycerides, Bil-total Bilirubin Total, Bil-direct Direct Bilirubin3.2.3. Post-hoc analysis result