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Table 3 Mean hematological parameters for 28 week repeated oral doses of E. kebericho decoction treated rats

From: Acute and sub-acute toxicity of Echinops kebericho decoction in rats

ParameterMaleFemaleP-value
Control150 mg/kg300 mg/kg600 mg/kgcontrol150 mg/kg300 mg/kg600 mg/kg 
WBC × 103
/μL
6.73 ± 4.207.31 ± 3.928.91 ± 1.798.34 ± 2.626.62 ± 1.165.88 ± 3.005.41 ± 1.986.60 ± 2.940.4956/0.8792
RBC ×106
/μL
8.80 ± 0.198.70 ± 0.568.78 ± 0.428.91 ± 0.898.26 ± 0.737.74 ± 0.387.93 ± 0.548.13 ± 0.370.0194*/0.6137
HGB (g/dl)16.14 ± 0.3715.88 ± 0.9016.08 ± 0.6016.46 ± 1.5615.78 ± 1.4215.26 ± 0.2515.42 ± 0.9615.70 ± 0.72800.5654/0.6188
HCT (%)45.74 ± 1.3644.98 ± 2.5346.64 ± 1.8647.64 ± 3.3145.82 ± 3.5444.40 ± 0.9844.06 ± 2.0044.80 ± 2.650.2559/0.5777
MCV (fL)51.96 ± 1.4951.68 ± 0.7153.18 ± 1.7353.50 ± 2.5655.56 ± 1.5056.46 ± 1.1254.26 ± 1.4655.06 ± 1.620.0023*/0.8887
MCH pg18.34 ± 0.3018.25 ± 0.1918.32 ± 0.3218.46 ± 0.4519.10 ± 0.4519.16 ± 0.1919.26 ± 0.5719.30 ± 0.290.0004*/0.6543
MCHC (g/dL)35.28 ± 0.5435.33 ± 0.1334.48 ± 0.7334.48 ± 1.1034.42 ± 0.4933.92 ± 0.5435.44 ± 0.2535.08 ± 0.630.0143*/0.7061
PLT ×103
/μL
1072 ± 90.91993.0 ± 32.371066 ± 89.121037 ± 142.91083 ± 56.891052 ± 72.991091 ± 51.52820.6 ± 372.10.4173/0.2238
RDW-SD(%)28.78 ± 0.8129.28 ± 0.9329.82 ± 1.1830.24 ± 0.3029.26 ± 0.9429.32 ± 1.2227.90 ± 1.0028.50 ± 1.390.0331*/0.7570
RDW-CV (fl)19.28 ± 0.2319.40 ± 0.9419.46 ± 0.6919.95 ± 0.7417.96 ± 1.2417.28 ± 0.7017.60 ± 1.1117.60 ± 1.080.0012*/0.8976
PDW (%)8.68 ± 0.228.52 ± 0.288.24 ± 0.118.60 ± 0.268.22 ± 0.418.38 ± 0.288.12 ± 0.228.28 ± 0.330.0429*/0.1478
MPV ×103
/μL
7.78 ± 0.167.80 ± 0.147.64 ± 0.157.80 ± 0.277.58 ± 0.227.74 ± 0.097.60 ± 0.167.72 ± 0.230.3858/0.2674
P-LCR (%)9.64 ± 1.019.72 ± 1.168.66 ± 0.629.70 ± 1.708.26 ± 1.369.20 ± 0.698.34 ± 1.189.12 ± 1.180.3365/0.2621
PCT (%)0.83 ± 0.060.78 ± 0.020.81 ± 0.060.81 ± 0.090.82 ± 0.040.81 ± 0.060.83 ± 0.030.63 ± 0.280.5053/0.2593
NEUT (%)16.54 ± 1.4322.70 ± 7.3122.03 ± 6.0525.66 ± 7.4717.50 ± 3.3716.64 ± 3.7521.90 ± 7.1517.98 ± 6.540.1442/0.3017
LYMPH (%)77.18 ± 1.6371.18 ± 7.6371.58 ± 6.2067.86 ± 7.6375.84 ± 4.4474.36 ± 4.6374.12 ± 7.4375.58 ± 6.3280.4319/0.3016
MONO (%)5.14 ± 1.434.72 ± 1.794.65 ± 2.055.56 ± 0.695.12 ± 1.437.52 ± 1.612.46 ± 1.423.22 ± 2.870.0231*/0.0295**
EO (%)0.86 ± 0.211.28 ± 0.441.58 ± 0.150.78 ± 0.111.40 ± 0.551.22 ± 0.371.24 ± 0.582.10 ± 2.080.0346*/0.1318
BASO (%)0.28 ± 0.250.12 ± 0.100.82 ± 1.440.14 ± 0.110.14 ± 0.050.26 ± 0.320.08 ± 0.110.52 ± 0.730.5610/0.8971
IG (%)0.16 ± 0.150.25 ± 0.170.17 ± 0.0960.24 ± 0.150.20 ± 0.190.08 ± 0.130.24 ± 0.0550.25 ± 0.210.6349/0.6137
  1. *Significant p-value when males and females are treated separately, ** significant p-value when males and females are grouped together; Where, PLT Platelets, RBC Red blood cells, WBC White blood cells, MCV Mean corpuscular volume, MCH Mean corpuscular hemoglobin, MCHC Mean corpuscular hemoglobin concentration, RDW Red cell distribution width, PDW Platelet volume distribution width, HCT Hematocrit, HGB Hemoglobin
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