From: Acute and sub-acute toxicity of Echinops kebericho decoction in rats
Organs | Male | Female | P-value | ||||||
---|---|---|---|---|---|---|---|---|---|
control | 150 mg/kg | 300 mg/kg | 600 mg/kg | Control | 150 mg/kg | 300 mg/kg | 600 mg/kg |  | |
Absolute weight | |||||||||
 Liver (in g) | 11.49 ± 1.04 | 12.13 ± 1.21 | 11.89 ± 2.41 | 9.19 ± 0.96 | 9.85 ± 2.18 | 9.42 ± 0.89 | 7.13 ± 0.56 | 9.12 ± 0.72 | – |
 Right kidney (in g) | 1.114 ± 0.17 | 1.22 ± 0.17 | 1.072 ± 0.17 | 1.04 ± 0.12 | 0.91 ± 0.12 | 0.94 ± 0.10 | 0.77 ± 0.08 | 0.86 ± 0.07 | – |
 Left kidney (in g) | 1.16 ± 0.16 | 1.25 ± 0.22 | 1.02 ± 0.13 | 0.98 ± 0.08 | 0.89 ± 0.08 | 0.912 ± 0.14 | 0.79 ± 0.09 | 0.87 ± 0.06 | – |
Spleen (in g) | 0.53 ± 0.04 | 0.66 ± 0.13 | 0.61 ± 0.16 | 0.65 ± 0.11 | 0.59 ± 0.16 | 0.63 ± 0.08 | 0.67 ± 0.07 | 0.63 ± 0.10 | – |
 Lung (in g) | 1.80 ± 0.30 | 1.86 ± 0.14 | 1.59 ± 0.13 | 1.59 ± 0.18 | 1.65 ± 0.13 | 1.44 ± 0.06 | 1.30 ± 0.13 | 1.19 ± 0.20 | – |
 Heart (in g) | 1.35 ± 0.042 | 1.42 ± 0.23 | 1.33 ± 0.20 | 1.19 ± 0.11 | 1.04 ± 0.04 | 1.02 ± 0.07 | 1.02 ± 0.13 | 1.02 ± 0.06 | – |
Relative organ weight (Organ weight in gram/100 g of animal weight) | |||||||||
 Liver | 3.21 ± 0.26 | 3.12 ± 0.21 | 3.13 ± 0.48 | 2.62 ± 0.35 | 3.61 ± 0.70 | 3.60 ± 0.18 | 3.00 ± 0.24 | 3.63 ± 0.37 | 0.0045*/0.2187 |
 Right kidney | 0.31 ± 0.04 | 0.31 ± 0.03 | 0.28 ± 0.03 | 0.29 ± 0.02 | 0.33 ± 0.04 | 0.36 ± 0.03 | 0.32 ± 0.03 | 0.34 ± 0.03 | 0.0497*/0.2743 |
 Left kidney | 0.32 ± 0.04 | 0.32 ± 0.05 | 0.27 ± 0.03 | 0.28 ± 0.02 | 0.33 ± 0.04 | 0.35 ± 0.03 | 0.33 ± 0.03 | 0.34 ± 0.02 | 0.0206*/0.2759 |
 Spleen | 0.15 ± 0.02 | 0.17 ± 0.03 | 0.16 ± 0.03 | 0.18 ± 0.04 | 0.22 ± 0.05 | 0.24 ± 0.04 | 0.28 ± 0.03 | 0.25 ± 0.03 | 0.0013* /0.3968 |
 Lung | 0.50 ± 0.06 | 0.48 ± 0.04 | 0.42 ± 0.02 | 0.45 ± 0.04 | 0.61 ± 0.05 | 0.55 ± 0.05 | 0.54 ± 0.04 | 0.47 ± 0.08 | 0.0015* /0.0277** |
 Heart | 0.38 ± 0.02 | 0.36 ± 0.05 | 0.35 ± 0.04 | 0.34 ± 0.02 | 0.38 ± 0.01 | 0.39 ± 0.02 | 0.43 ± 0.07 | 0.40 ± 0.04 | 0.0409*/0.9093 |