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Table 4 Comparative inhibitory effects of E. hirta extract and its fractions in isolated rabbit jejunum

From: The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms

Sr. no. Test material EC50 (mg/mL) value (95% CI; n = 4–6) against spontaneous movement EC50 (mg/mL) value (95% CI; n = 4–6) against high K+ (80 mM)-induced contractions EC50 (mg/mL) value (95% CI; n = 4–6) against low K+ (20 mM)-induced contractions
1. EH.Cr without atropine 5.09 (2.72–9.51) 1.90 (1.09–3.26) 1.89 (1.07–3.28)
with atropine 3.36 (1.86–6.03)
2. Pet.EH without atropine 0.28 (0.032–2.43) 0.19 (0.05–0.62) 0.19 (0.06–0.60)
with atropine 0.29 (0.07–1.08)
3. CHCl3.EH without atropine 0.40 (0.26–0.61) 0.83 (0.35–1.95) 0.83 (0.32–1.90)
with atropine 0.32 (0.21–0.48)
4. Et.Ac.EH without atropine 2.53 (1.59–4.04) 1.38 (0.86–2.19) 1.38 (0.88–2.2)
with atropine 1.55 (0.88–2.71)
5. Aq.EH without atropine N/A N/A N/A
with atropine 6.35 (2.78–14.48)
6. Quercetin without atropine 2.57 (1.63–4.03) 2.57 (1.63–4.03) 2.50 (1.55–4.1)
with atropine 2.57 (1.63–4.03)
7. Nifedipine without atropine 0.13 (0.11–0.44) 0.13 (0.11–0.44) 0.13 (0.11–0.44)
with atropine 0.13 (0.11–0.44)
  1. Values showed geometric means with 95% confidence intervals (CI) in parenthesis. “n” shows number of experiments
  2. Abbreviations: EH.Cr the crude extract of E. hirta, Pet.EH petroleum ether fraction, CHCl3.EH chloroform fraction, Et.Ac.EH ethyl acetate fraction, Aq.EH aqueous fraction