Sr. no.
|
Test material
|
EC50 (mg/mL) value (95% CI; n = 4–6) against spontaneous movement
|
EC50 (mg/mL) value (95% CI; n = 4–6) against high K+ (80 mM)-induced contractions
|
EC50 (mg/mL) value (95% CI; n = 4–6) against low K+ (20 mM)-induced contractions
|
---|
1.
|
EH.Cr
|
without atropine
|
5.09 (2.72–9.51)
|
1.90 (1.09–3.26)
|
1.89 (1.07–3.28)
|
with atropine
|
3.36 (1.86–6.03)
|
2.
|
Pet.EH
|
without atropine
|
0.28 (0.032–2.43)
|
0.19 (0.05–0.62)
|
0.19 (0.06–0.60)
|
with atropine
|
0.29 (0.07–1.08)
|
3.
|
CHCl3.EH
|
without atropine
|
0.40 (0.26–0.61)
|
0.83 (0.35–1.95)
|
0.83 (0.32–1.90)
|
with atropine
|
0.32 (0.21–0.48)
|
4.
|
Et.Ac.EH
|
without atropine
|
2.53 (1.59–4.04)
|
1.38 (0.86–2.19)
|
1.38 (0.88–2.2)
|
with atropine
|
1.55 (0.88–2.71)
|
5.
|
Aq.EH
|
without atropine
|
N/A
|
N/A
|
N/A
|
with atropine
|
6.35 (2.78–14.48)
|
6.
|
Quercetin
|
without atropine
|
2.57 (1.63–4.03)
|
2.57 (1.63–4.03)
|
2.50 (1.55–4.1)
|
with atropine
|
2.57 (1.63–4.03)
|
7.
|
Nifedipine
|
without atropine
|
0.13 (0.11–0.44)
|
0.13 (0.11–0.44)
|
0.13 (0.11–0.44)
|
with atropine
|
0.13 (0.11–0.44)
|
- Values showed geometric means with 95% confidence intervals (CI) in parenthesis. “n” shows number of experiments
- Abbreviations: EH.Cr the crude extract of E. hirta, Pet.EH petroleum ether fraction, CHCl3.EH chloroform fraction, Et.Ac.EH ethyl acetate fraction, Aq.EH aqueous fraction