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Table 3 Laxative effect of E. hirta extract in loperamide–induced constipated mice

From: The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms

Group no. Treatment Dose (mg/kg) Mean defecation/group Mean amount of wet feces/group % Wet feces
1. Saline (10 mL/kg) 10 8.21 ± 0.45 0.79 ± 0.12 9.63
2. Loperamide + saline 5 + 10 2.31 ± 0.14*** 0.20 ± 0.09* 8.6
3. Loperamide + EH.Cr (p.o) 5 + 50 4.16 ± 0.13 @@/++ 1.19 ± 0.38 ns/ns 28.6
4. Loperamide + EH.Cr (p.o) 5 + 100 5.1 ± 0.35 @@/++ 1.80 ± 0.31 @@/ + 35.3
  1. Values are presented as mean ± SEM, n = 6 animals/group. *p < 0.05 and ***p < 0.001 show a comparison of group no. 2 vs group no. 1 (Students t-test). @ p < 0.05 and @@ p < 0.01 show a comparison of group no. 3 and 4 vs group no. 2. + p < 0.05 and ++ p < 0.01 show a comparison of group no. 3 and 4 vs group no. 1, ns represents non-significant (One-way ANOVA followed by Dunnett’s test)