|
Group no.
|
Treatment
|
Dose (mg/kg)
|
Mean defecation/group
|
Mean amount of wet feces/group
|
% Wet feces
|
|---|
|
1.
|
Saline (10 mL/kg)
|
10
|
8.21 ± 0.45
|
0.79 ± 0.12
|
9.63
|
|
2.
|
Loperamide + saline
|
5 + 10
|
2.31 ± 0.14***
|
0.20 ± 0.09*
|
8.6
|
|
3.
|
Loperamide + EH.Cr (p.o)
|
5 + 50
|
4.16 ± 0.13 @@/++
|
1.19 ± 0.38 ns/ns
|
28.6
|
|
4.
|
Loperamide + EH.Cr (p.o)
|
5 + 100
|
5.1 ± 0.35 @@/++
|
1.80 ± 0.31 @@/ +
|
35.3
|
- Values are presented as mean ± SEM, n = 6 animals/group. *p < 0.05 and ***p < 0.001 show a comparison of group no. 2 vs group no. 1 (Students t-test). @ p < 0.05 and @@ p < 0.01 show a comparison of group no. 3 and 4 vs group no. 2. + p < 0.05 and ++ p < 0.01 show a comparison of group no. 3 and 4 vs group no. 1, ns represents non-significant (One-way ANOVA followed by Dunnett’s test)
