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Table 2 Laxative effect of E. hirta extract in the absence and presence of atropine in mice

From: The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms

Group no. Treatment Dose (mg/Kg) Mean pellets/group (numbers) Mean wet pellets/group (numbers) % Laxation
1 Saline (10 mL/kg) 4.5 ± 0.42 0.333 ± 0.21 7.40
2 Carbachol 1 11.6 ± 0.67 ** 6.33 ± 1.22 ** 54.3
3 EH.Cr (p.o) 50 7.33 ± 0.49 * 3 ± 0.36 ** 40.9
4 EH.Cr (p.o) 100 8.5 ± 0.42 ** 5.10 ± 0.57 ** 58.8
5 EH.Cr (p.o) 300 3.53 ± 0.42 1.66 ± 0.30 28.5
6 Saline (10 mL/kg) + atropine 10 3.11 ± 0.36 0.00 ± 0.00 0
7 Carbachol + atropine (i.p) 1 + 10 6 ± 1.30 @@ 1.66 ± 0.33 @@ 27.7
8 EH.Cr (p.o) + atropine (i.p) 50 + 10 3.5 ± 0.56 @@ 0.83 ± 0.30 @ 23.8
9 EH.Cr (p.o) + atropine (i.p) 100 + 10 4.83 ± 1.07@@ 1.33 ± 0.49 @@ 27.5
10 EH.Cr (p.o) + atropine (i.p) 300 + 10 1.33 ± 0.21ns 0.33 ± 0.22 ns 25
  1. Abbreviations: EH.Cr the crude extract of E. hirta, p.o. per oral, i.p intraperitoneal
  2. Values are presented as mean ± SEM, n = 6 animals/group. */@ p < 0.05, **/@@ p < 0.01 and ns indicates non-significant, * shows comparison of group 2–5 vs group 1, (One-way ANOVA followed by Dunnett’s test), @ shows a comparison of group 7 vs group 2, group 8 vs 3, group 9 vs 4 and group 10 vs 5 (One-way ANOVA followed by Bonferroni test)