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Table 1 Antidiarrheal effect of E. hirta extract against castor oil-induced diarrhea in mice

From: The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms

Group no. Treatment Dose (mg/kg) Mean feces/group (numbers) Mean wet feces/group (numbers) % age protection from diarrhea
1 Saline + castor oil (10 mL/kg) 8.5 ± 1.78 6.82 ± 0.47 18%
2 Loperamide + castor oil 10 2.83 ± 0.60 ** 0 ± 0.00 ** 100%
3 EH Cr. (p.o) + castor oil 500 4.83 ± 0.40 * 2.85 ± 1.24* 41%
4 EH Cr. (p.o) + castor oil 1000 3.84 ± 0.54 ** 1.16 ± 1.16** 70%
5 Quercetin + castor oil (p.o) 50 8.16 ± 053 4.16 ± 1.07* 46%
6 Quercetin + castor oil (p.o) 100 7.66 ± 0.61 3.33 ± 0.91* 56%
7 Quercetin + castor oil (p.o) 150 7.33 ± 0.80 2.50 ± 1.41* 65%
  1. Abbreviations: EH.Cr the crude extract of E. hirta, p.o. per oral
  2. Values shown are mean ± SEM n = six animals/group. *p<0.05 and **p<0.01 show a comparison of group 2–7 versus group 1 (One way ANOVA followed by Dunnet’s test)