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Table 1 Effects of the swelling of feet in rats induced by vinegar-processed RAR (\( \overline{\mathrm{x}} \) ± s, n = 10)

From: Comparison of the acute toxicity, analgesic and anti-inflammatory activities and chemical composition changes in Rhizoma anemones Raddeanae caused by vinegar processing

Group

Blank group

Model group

Methotrexate group

RAR group

Vinegar-processed RAR group

Dose (mg/kg)

0

0

5

336

336

0.5 h Swell (mm)

4.32 ± 0.50

7.79 ± 0.84

6.83 ± 0.95

7.22 ± 0.45

7.13 ± 0.55

0.5 h Inhibition Rate (%)

0%

80.32%

58.10%

67.13%

65.05%

1.0 h Swell (mm)

4.92 ± 0. 83

8.42 ± 0.56

7.45 ± 0.42

7.41 ± 0.99

7.02 ± 0.23

1.0 h Inhibition Rate (%)

0%

71.13%

51.42%

50.61%

42.68%

2.0 h Swell (mm)

5.21 ± 0. 46

8.57 ± 0.28

7.56 ± 0.25

6.87 ± 0.36*

6.56 ± 0.41*

2.0 h Inhibition Rate (%)

0%

64.49%

45.11%

31.86%

25.91%

3.0 h Swell (mm)

5.13 ± 0.92

8.32 ± 0.39

6.59 ± 0.68*

6.32 ± 0.26**

6.28 ± 0.37**

3.0 h Inhibition Rate (%)

0%

62.18%

28.46%

23.30%

22.42%

4.0 h Swell (mm)

4.97 ± 0. 71

7.95 ± 0.17

6.33 ± 0.48**

6.08 ± 0.78**

6.02 ± 0.21**

4.0 h Inhibition Rate (%)

0%

60.00%

27.36%

22.33%

21.13%

6.0 h Swell (mm)

4.33 ± 0. 19

7.21 ± 0.44

5.02 ± 0.74**

5.30 ± 0.59**

4.98 ± 0.29**

6.0 h Inhibition Rate (%)

0%

66.51%

15.94%

22.40%

15.01%