Table 3 Level of evidence assessment using GRADE approach for the outcomes
Study | Risk of bias | Imprecision | Inconsistency | Indirectness | Publication bias | Level of evidence |
|---|---|---|---|---|---|---|
Marsdenia tenacissima extract in adjutant with chemotherapy for management of gastric cancer | ||||||
Response to treatment | -1 | −0 | − 0 | − 0 | − 1 | Low |
Performance status | −1 | − 1 | − 0 | − 0 | − 0 | Low |
Marsdenia tenacissima extract for reducing adverse effect of chemotherapy | ||||||
Leukopenia | −1 | −0 | − 0 | − 0 | − 0 | Moderate |
Thrombocytopenia | − 1 | − 0 | − 0 | − 0 | − 0 | Moderate |
Anemia | −1 | − 1 | − 0 | − 0 | −0 | Low |
Nausea/vomiting | − 1 | −0 | −0 | − 0 | −0 | Moderate |
Diarrhea | −1 | − 1 | −0 | −0 | − 0 | Low |
Constipation | −1 | −2 | −0 | −0 | − 0 | Very low |
Hepatic injury | −1 | −0 | −0 | − 0 | −0 | Low |
Kidney injury | −2 | − 2 | −0 | −0 | − 0 | Very low |
Peripheral neurotoxicity | −1 | −0 | −0 | − 0 | −0 | Moderate |
Oral mucosal lesions | −1 | − 1 | −0 | −0 | − 0 | Low |