| Study | Risk of bias | Imprecision | Inconsistency | Indirectness | Publication bias | Level of evidence |
|---|
| Marsdenia tenacissima extract in adjutant with chemotherapy for management of gastric cancer |
| Response to treatment | -1 | −0 | − 0 | − 0 | − 1 | Low |
| Performance status | −1 | − 1 | − 0 | − 0 | − 0 | Low |
| Marsdenia tenacissima extract for reducing adverse effect of chemotherapy |
| Leukopenia | −1 | −0 | − 0 | − 0 | − 0 | Moderate |
| Thrombocytopenia | − 1 | − 0 | − 0 | − 0 | − 0 | Moderate |
| Anemia | −1 | − 1 | − 0 | − 0 | −0 | Low |
| Nausea/vomiting | − 1 | −0 | −0 | − 0 | −0 | Moderate |
| Diarrhea | −1 | − 1 | −0 | −0 | − 0 | Low |
| Constipation | −1 | −2 | −0 | −0 | − 0 | Very low |
| Hepatic injury | −1 | −0 | −0 | − 0 | −0 | Low |
| Kidney injury | −2 | − 2 | −0 | −0 | − 0 | Very low |
| Peripheral neurotoxicity | −1 | −0 | −0 | − 0 | −0 | Moderate |
| Oral mucosal lesions | −1 | − 1 | −0 | −0 | − 0 | Low |
- Note: In GRADE instrument, the level of evidence of outcomes is judged as high, moderate, low, and very low if the total score is “-0”, “-1”, “-2”, and “≥ −3”, respectively
