|
Study
|
Risk of bias
|
Imprecision
|
Inconsistency
|
Indirectness
|
Publication bias
|
Level of evidence
|
|---|
|
Marsdenia tenacissima extract in adjutant with chemotherapy for management of gastric cancer
|
|
Response to treatment
|
-1
|
−0
|
− 0
|
− 0
|
− 1
|
Low
|
|
Performance status
|
−1
|
− 1
|
− 0
|
− 0
|
− 0
|
Low
|
|
Marsdenia tenacissima extract for reducing adverse effect of chemotherapy
|
|
Leukopenia
|
−1
|
−0
|
− 0
|
− 0
|
− 0
|
Moderate
|
|
Thrombocytopenia
|
− 1
|
− 0
|
− 0
|
− 0
|
− 0
|
Moderate
|
|
Anemia
|
−1
|
− 1
|
− 0
|
− 0
|
−0
|
Low
|
|
Nausea/vomiting
|
− 1
|
−0
|
−0
|
− 0
|
−0
|
Moderate
|
|
Diarrhea
|
−1
|
− 1
|
−0
|
−0
|
− 0
|
Low
|
|
Constipation
|
−1
|
−2
|
−0
|
−0
|
− 0
|
Very low
|
|
Hepatic injury
|
−1
|
−0
|
−0
|
− 0
|
−0
|
Low
|
|
Kidney injury
|
−2
|
− 2
|
−0
|
−0
|
− 0
|
Very low
|
|
Peripheral neurotoxicity
|
−1
|
−0
|
−0
|
− 0
|
−0
|
Moderate
|
|
Oral mucosal lesions
|
−1
|
− 1
|
−0
|
−0
|
− 0
|
Low
|
- Note: In GRADE instrument, the level of evidence of outcomes is judged as high, moderate, low, and very low if the total score is “-0”, “-1”, “-2”, and “≥ −3”, respectively
