Study | Risk of bias | Imprecision | Inconsistency | Indirectness | Publication bias | Level of evidence |
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Marsdenia tenacissima extract in adjutant with chemotherapy for management of gastric cancer |
Response to treatment | -1 | −0 | − 0 | − 0 | − 1 | Low |
Performance status | −1 | − 1 | − 0 | − 0 | − 0 | Low |
Marsdenia tenacissima extract for reducing adverse effect of chemotherapy |
Leukopenia | −1 | −0 | − 0 | − 0 | − 0 | Moderate |
Thrombocytopenia | − 1 | − 0 | − 0 | − 0 | − 0 | Moderate |
Anemia | −1 | − 1 | − 0 | − 0 | −0 | Low |
Nausea/vomiting | − 1 | −0 | −0 | − 0 | −0 | Moderate |
Diarrhea | −1 | − 1 | −0 | −0 | − 0 | Low |
Constipation | −1 | −2 | −0 | −0 | − 0 | Very low |
Hepatic injury | −1 | −0 | −0 | − 0 | −0 | Low |
Kidney injury | −2 | − 2 | −0 | −0 | − 0 | Very low |
Peripheral neurotoxicity | −1 | −0 | −0 | − 0 | −0 | Moderate |
Oral mucosal lesions | −1 | − 1 | −0 | −0 | − 0 | Low |
- Note: In GRADE instrument, the level of evidence of outcomes is judged as high, moderate, low, and very low if the total score is “-0”, “-1”, “-2”, and “≥ −3”, respectively