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Table 3 Adverse events (AEs)

From: Effects of fish oil supplement on psoriasis: a meta-analysis of randomized controlled trials

Study IDInterventionAdverse events
Bjørneboe 1988 [13]Fish oilRoutine lab: none of the parameters changed significantly during the trial (CBC, ESR, creatinine, albumin, ALT, GGT, bleeding time, triglyceride, cholesterol).
Danno 1998 [14]Fish oil + EtretinateCheilitis, dry mouth, dry eyes, desquamation of palms, folliculitis, gastric symptoms, and increased liver enzymes. All were mild or tolerable. No significant difference in the incidence between intervention and control groups.
Grimminger 1993 [15]Fish oil (intravenous)No obvious side effect except for rare irritations at the site of peripheral intravenous route; routine lab: not change substantially (ESR, CRP, cholesterol, triglyceride, BUN, ALT, GGT, amylase, lipase, coagulation variables).
Gupta 1989 [17]Fish oil + UVB phototherapyNo side effect was reported in either group.
Gupta 1990 [16]Fish oil + betamethasone
diproprionate cream
An occasional fishy taste upon eructation in one patient on fish oil and one on olive oil therapy; transient diarrhea at beginning of therapy in 2 patients on fish oil
Kristensen 2018 [18]Fish oilMild gastrointestinal adverse effects (9 in intervention group and 6 in control group)
Mayser 1998 [20]Fish oil (intravenous) + 3% salicyclic acidMost frequently reported in intervention group: superficial thrombophlebitis; most frequently reported in control group: superficial thrombophlebitis, pruritus, hypertriglyceridemia, and fever; no severe AEs; routine lab: not substantially change (AST, ALT, Alk-P, creatinine, blood glucose, CBC/DC, total cholesterol, triglyceride)
Strong 1993 [23]Fish oil + evening primrose oilBlood test: remained unchanged throughout the trial (CBC, urea, creatinine, total lipids, HDL and LDL, cholesterol, triglyceride, electrolytes)
Veale 1994 [24]Fish oil + evening primrose oilNo significant differences in lab indices including ESR, CRP, hemoglobin, urea, electrolytes, liver enzymes
  1. Alk-P Alkaline phosphatase, ALT Alanine aminotransferase, AST Aspartate aminotransferase, BUN Blood urea nitrogen, CBC Complete blood count, CRP C-reactive protein, DC Differential count, ESR Erythrocyte sedimentation rate, GGT Gamma glutamyl transpeptidase