Table 4 IC50 values of inhibition towards beta-hexosaminidase and histamine release
From: In vitro anti-allergic activity of Moringa oleifera Lam. extracts and their isolated compounds
IC50 values of inhibition | ||
|---|---|---|
Beta-hexosaminidase | Histamine | |
M. oleifera leaf extract | 7.17 ± 1.69 μg/mL** | 11.66 ± 1.26 μg/mL |
M. oleifera seed extract | 10.68 ± 0.63 μg/mL | 5.97 ± 0.84 μg/mL |
M. oleifera pod extract | 14.89 ± 1.25 μg/mL | 7.43 ± 1.01 μg/mL |
Ethyl-(E)–undec-6-enoate (1) | 82.68 ± 1.98 μM | 82.07 ± 13.75 μM |
3,5,6-trihydroxy-2-(2,3,4,5,6-pentahydroxyphenyl)-4H-chromen-4-one (2) | 17.70 ± 23.29 μM | 44.87 ± 2.13 μM |
Quercetin (3) | 19.07 ± 7.19 μM* | 7.77 ± 27.86 μM |
Kaempferol (4) | 29.39 ± 6.26 μM | 46.94 ± 10.26 μM |
β-sitosterol-3-O-glucoside (5) | 24.93 ± 2.10 μM | – |
Oleic acid (6) | 53.76 ± 8.95 μM | 56.05 ± 37.11 μM |
Glucomoringin (7) | 10.43 ± 1.51 μM* | 27.22 ± 18.62 μM |
Stigmasterol (9) | 75.92 ± 4.66 μM | 38.27 ± 24.48 μM |
Ketotifen fumarate (positive control) | 15.19 ± 1.10 μg/mL (35.70 ± 2.59 μM) | 6.97 ± 0.04 μg/mL (16.38 ± 0.10 μM) |