Table 6 Blood chemical parameters
From: A 13-Week Repeated Oral Dose Toxicity Study of ChondroT in Sprague-Dawley Rats
Parameters | Group(Dose)* | G1(0) | G2(500) | G3(1000) | G4(2000) | ||
|---|---|---|---|---|---|---|---|
Sex/Week | 13week | 17week# | 13week | 13week | 13week | 17week# | |
Total protein(g/dL) | Male | 5.9±0.4 | 5.8±0.3 | 5.9±0.3 | 6.1±0.3 | 6.1±0.1 | 6.0±0.3 |
Female | 6.4±0.5 | 6.6±0.5 | 6.7±0.5 | 6.5±0.5 | 6.6±0.4 | 6.4±0.3 | |
Albumin(g/dL) | Male | 3.8±0.2 | 3.9±0.2 | 3.8±0.1 | 3.9±0.2 | 4.0±0.1 | 3.9±0.2 |
Female | 4.2±0.3 | 4.4±0.3 | 4.4±0.3 | 4.3±0.3 | 4.4±0.2 | 4.2±0.3 | |
A/G ratio | Male | 1.9±0.1 | 2.0±0.1 | 1.9±0.1 | 1.8±0.1 | 1.9±0.1 | 1.8±0.1 |
Female | 2.1±0.1 | 2.1±0.2 | 1.9±0.1 | 2.0±0.1 | 2.0±0.1 | 1.9±0.1 | |
Total bilirubin(mg/dL) | Male | 0.0±0.0 | 0.04±0.01 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 0.03±0.01 |
Female | 0.0±0.0 | 0.05±0.04 | 0.1±0.0 | 0.1±0.1 | 0.1±0.0 | 0.05±0.02 | |
Alkaline phosphatase(U/L) | Male | 305.3±66.1 | 240.4±55.7 | 279.8±50.9 | 294.6±48.2 | 259.4±50.4 | 236.8±17.4 |
Female | 145.8±46.6 | 108.0±51.9 | 166.2±73.0 | 168.9±70.8 | 150.6±44.0 | 135.8±40.1 | |
Aspartate aminotransferase(U/L) | Male | 97.0±21.9 | 130.2±42.4 | 102.1±23.9 | 107.0±35.7 | 105.9±36.9 | 85.4±8.4 |
Female | 91.8±22.4 | 123.8±23.6 | 105.0±24.2 | 87.9±21.2 | 87.4±23.7 | 113.8±9.1 | |
Alanine aminotransferase(U/L) | Male | 35.1±7.9 | 46.0±15.9 | 32.5±5.9 | 31.0±5.5 | 32.2±5.8 | 30.8±6.6 |
Female | 35.8±10.8 | 36.4±7.8 | 37.7±10.7 | 33.0±12.0 | 31.4±9.8 | 48.8±14.6 | |
Creatinine(mg/dL) | Male | 0.4±0.0 | 0.5±0.0 | 0.4±0.0 | 0.4±0.0 | 0.4±0.0 | 0.4±0.1 |
Female | 0.5±0.1 | 0.5±0.0 | 0.5±0.0 | 0.5±0.1 | 0.5±0.1 | 0.5±0.0 | |
Blood urea nitrogen(mg/dL) | Male | 15.0±1.4 | 14.1±1.4 | 13.0±1.8 | 14.1±2.7 | 14.6±2.1 | 14.5±1.2 |
Female | 16.4±3.0 | 19.7±4.7 | 16.9±3.6 | 16.4±3.0 | 16.9±2.0 | 16.5±1.2 | |
Total cholesterol(mg/dL) | Male | 56.7±19.7 | 58.6±14.4 | 58.4±11.8 | 56.7±17.7 | 65.0±15.2 | 77.6±19.2 |
Female | 59.0±15.3 | 63.6±10.4 | 69.7±12.3 | 76.4±28.2 | 70.7±11.2 | 73.4±6.9 | |
Triglycerides(mg/dL) | Male | 22.0±12.1 | 30.2±22.3 | 26.3±5.8 | 25.2±8.0 | 32.8±14.3 | 37.0±11.6 |
Female | 14.2±4.9 | 26.2±14.3 | 23.1±10.9 | 18.6±7.7 | 25.4±9.2** | 18.0±3.3 | |
Glucose(mg/dL) | Male | 153.5±18.6 | 174.4±18.2 | 160.6±25.1 | 151.1±17.6 | 153.0±21.2 | 191.4±37.0 |
Female | 144.6±14.4 | 162.8±17.6 | 158.4±11.7 | 168.0±32.6 | 156.3±12.8 | 162.0±18.7 | |
Calcium(mg/dL) | Male | 9.3±0.4 | 8.8±0.1 | 9.3±0.3 | 9.3±0.3 | 9.6±0.2 | 8.9±0.1 |
Female | 9.3±0.4 | 9.0±0.3 | 9.5±0.3 | 9.4±0.4 | 9.4±0.3 | 8.9±0.2 | |
Inorganic phosphorus(mg/dL) | Male | 6.1±0.6 | 5.1±0.3 | 5.9±0.4 | 5.7±0.6 | 5.9±0.4 | 5.0±0.4 |
Female | 4.5±1.0 | 3.7±0.9 | 4.9±1.1 | 4.7±1.0 | 4.7±1.0 | 3.3±0.5 | |
Creatine kinase(U/L) | Male | 305.8±184.8 | 392.8±184.1 | 402.7±266.3 | 461.3±412.7 | 414.2±408.6 | 262.0±112.5 |
Female | 206.5±135.2 | 525.8±260.9 | 292.1±267.7 | 192.0±80.9 | 222.7±139.0 | 384.8±260.2 | |
Sodium(mmol/L) | Male | 145.7±0.9 | 146.3±1.0 | 145.7±0.6 | 146.1±0.8 | 146.7±0.6** | 145.9±1.4 |
Female | 144.4±1.3 | 145.3±0.8 | 144.8±0.9 | 144.9±0.0 | 143.8±1.0 | 144.8±0.4 | |
Potassium(mmol/L) | Male | 4.7±0.2 | 4.5±0.3 | 4.7±0.3 | 4.5±0.4 | 4.6±0.4 | 4.5±0.5 |
Female | 3.9±0.2 | 4.31±0.35 | 4.2±0.6 | 4.2±0.3 | 4.1±0.2 | 4.52±0.23 | |
Chloride(mmol/L) | Male | 106.9±1.7 | 106.6±1.0 | 105.8±0.9 | 106.4±1.0 | 106.0±1.4 | 106.4±2.1 |
Female | 107.2±1.4 | 107.8±1.0 | 106.8±2.1 | 106.2±1.6 | 106.0±1.9 | 108.1±1.1 | |