A 13-Week Repeated Oral Dose Toxicity Study of ChondroT in Sprague-Dawley Rats

Table 4 Clinical signs observed in the 13-week repeated oral dose toxicity study with SD rats

Group (Dose)^*	Week	Sex	Number of rats	Weeks / Number of rats observed clinical signs																	Mortality (dead/total)
Group (Dose)^*	Week	Sex	Number of rats	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
G1 (0)	13	Male	10	0	0	0	0	0	0	0	0	0	0	0	0	0	-	-	-	-	0%
	13	Female	10	0	0	0	0	0	0	0	0	0	0	0	0	0	-	-	-	-	0%
	17^#	Male	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0%
	17^#	Female	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0%
G2 (500)	13	Male	10	0	0	0	0	0	0	0	0	0	0	0	0	0	-	-	-	-	0%
G2 (500)	13	Female	10	0	1^**	1^**	1^**	1^**	1^**	1^##	1^##	2^##	2^##	2^##	2^##	2^##	-	-	-	-	0%
G3 (1000)	13	Male	10	0	0	0	0	0	0	0	0	0	0	0	0	0	-	-	-	-	0%
G3 (1000)	13	Female	10	0	0	0	0	0	0	0	0	0	0	0	0	0	-	-	-	-	0%
G4 (2000)	13	Male	10	0	0	0	0	0	0	0	0	0	0	0	0	0	-	-	-	-	0%
	13	Female	10	0	0	0	0	0	0	0	0	0	0	0	0	0	-	-	-	-	0%
	17^#	Male	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0%
	17^#	Female	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0%

^* : mg/kg, - : not applicable, ^# : Recovery group, ^** : Loss of fur of posterior neck and abdomen(No.2308), ^## : Loss of fur of posterior neck and abdomen(No.2308), Slightly hard egg-shaped nodule of right neck(No. 2302)

ISSN: 2662-7671