Table 3 KEGG pathway enrichment and interacting proteins or targets

00910

Nitrogen metabolism

5.93e-21

CA1,CA12,CA13,CA14,CA2,CA3,CA4,CA5A,CA5B,CA6,CA7,CA9

04520

Adherens junction

3.81e-12

ACP1,EGFR,ERBB2,FGFR1,FYN,INSR,MET,PTPN1,PTPN6,PTPRF,SRC,YES1

04151

PI3K-Akt signalling pathway

6.47e-09

CDK4,CDK6,CHRM1,CHRM2,CSF1R,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,FLT1,FLT4,INSR,KDR,KIT,MET,NOS3

04014

Ras signalling pathway

1.22e-08

CSF1R,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,FLT1,FLT4,INSR,KDR,KIT,MET,PLA2G1B,PTPN11

04015

Rap1 signalling pathway

4.72e-08

CSF1R,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,FLT1,FLT4,INSR,KDR,KIT,MET,SRC

04913

Ovarian steroidogenesis

5.27e-08

ALOX5,CYP17A1,CYP19A1,CYP1B1,HSD17B1,HSD17B2,INSR,LDLR

04144

Endocytosis

1.93e-07

CSF1R,EGFR,ERBB4,FGFR2,FGFR3,FGFR4,FLT1,KDR,KIT,LDLR,MET,SRC

00590

Arachidonic acid metabolism

2.04e-07

ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,CYP2C19,PLA2G1B,PTGES

05206

MicroRNAs in cancer

1.05e-06

ABCB1,ABCC1,CDC25A,CDC25B,CDK6,CYP1B1,EGFR,ERBB2,FGFR3,MET

00140

Steroid hormone biosynthesis

1.44e-06

CYP17A1,CYP19A1,CYP1A2,CYP1B1,HSD11B1,HSD17B1,HSD17B2

01100

Metabolic pathways

2.81e-06

AKR1A1,AKR1B1,AKR1B10,ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,AOX1,CYP17A1,CYP19A1,CYP1A2,CYP2C19,CYP51A1,GBA,HMGCR,HSD11B1,HSD17B1,HSD17B2,NOS1,NOS2,NOS3,PLA2G1B,PTGES,XDH

05200

Pathways in cancer

4.18e-06

AR,CDK4,CDK6,CSF1R,EGFR,ERBB2,FGFR1,FGFR2,FGFR3,KIT,MET,MMP2,NOS2

05205

Proteoglycans in cancer

4.18e-06

EGFR,ERBB2,ERBB4,ESR1,FGFR1,KDR,MET,MMP2,PTPN11,PTPN6,SRC

04810

Regulation of actin cytoskeleton

2.22e-05

CHRM1,CHRM2,CHRM4,CHRM5,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,SRC

04020

Calcium signalling pathway

4e-05

CHRM1,CHRM2,CHRM5,EGFR,ERBB2,ERBB4,NOS1,NOS2,NOS3

05219

Bladder cancer

7.13e-05

CDK4,EGFR,ERBB2,FGFR3,MMP2

04976

Bile secretion

8.95e-05

ABCB1,ABCC2,ABCG2,CA2,HMGCR,LDLR

04726

Serotonergic synapse

0.000115

ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,CYP2C19,SLC6A4

00591

Linoleic acid metabolism

0.000464

ALOX15,CYP1A2,CYP2C19,PLA2G1B

04915

Estrogen signalling pathway

0.000464

EGFR,ESR1,ESR2,MMP2,NOS3,SRC

04510

Focal adhesion

0.000734

EGFR,ERBB2,FLT1,FLT4,FYN,KDR,MET,SRC

04066

HIF-1 signalling pathway

0.000751

EGFR,ERBB2,FLT1,INSR,NOS2,NOS3

04080

Neuroactive ligand-receptor interaction

0.000844

ADRA2A,ADRA2B,ADRA2C,CHRM1,CHRM2,CHRM4,CHRM5,

NR3C1,PRSS1

04725

Cholinergic synapse

0.000851

ACHE,CHRM1,CHRM2,CHRM4,CHRM5,FYN

05218

Melanoma

0.000996

CDK4,CDK6,EGFR,FGFR1,MET

05204

Chemical carcinogenesis

0.0011

CYP1A2,CYP1B1,CYP2C19,HSD11B1,MGST1

02010

ABC transporters

0.00138

ABCB1,ABCC1,ABCC2,ABCG2

05215

Prostate cancer

0.00239

AR,EGFR,ERBB2,FGFR1,FGFR2

00232

Caffeine metabolism

0.00402

CYP1A2,XDH

05223

Non-small cell lung cancer

0.00402

CDK4,CDK6,EGFR,ERBB2

05212

Pancreatic cancer

0.00619

CDK4,CDK6,EGFR,ERBB2

00982

Drug metabolism - cytochrome P450

0.00678

AOX1,CYP1A2,CYP2C19,MGST1

05120

Epithelial cell signalling in Helicobacter pylori infection

0.0074

EGFR,MET,PTPN11,SRC

00980

Metabolism of xenobiotics by cytochrome P450

0.00805

CYP1A2,CYP1B1,HSD11B1,MGST1

04917

Prolactin signaling pathway

0.00873

CYP17A1,ESR1,ESR2,SRC

00040

Pentose and glucuronate interconversions

0.01

AKR1A1,AKR1B1,AKR1B10

04010

MAPK signalling pathway

0.01

CDC25B,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,MAPT

04060

Cytokine-cytokine receptor interaction

0.0119

CSF1R,EGFR,FLT1,FLT4,KDR,KIT,MET

00380

Tryptophan metabolism

0.0151

AOX1,CYP1A2,CYP1B1

04012

ErbB signalling pathway

0.0151

EGFR,ERBB2,ERBB4,SRC

04022

cGMP-PKG signalling pathway

0.0256

ADRA2A,ADRA2B,ADRA2C,INSR,NOS3

05202

Transcriptional mis-regulation in cancer

0.03

CSF1R,FLT1,MET,MMP3,MPO

00561

Glycolipid metabolism

0.0349

AKR1A1,AKR1B1,AKR1B10

00330

Arginine and proline metabolism

0.0397

NOS1,NOS2,NOS3

04370

VEGF signalling pathway

0.0418

KDR,NOS3,SRC

04964

Proximal tubule bicarbonate reclamation

0.0418

CA2,CA4

05214

Glioma

0.0449

CDK4,CDK6,EGFR

04110

Cell cycle

0.0483

CDC25A,CDC25B,CDK4,CDK6