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Table 3 KEGG pathway enrichment and interacting proteins or targets

From: Systems pharmacology based approach to investigate the in-vivo therapeutic efficacy of Albizia lebbeck (L.) in experimental model of Parkinson’s disease

KEGG IDpathway descriptionFalse discovery rateInteracting proteins or targets
00910Nitrogen metabolism5.93e-21CA1,CA12,CA13,CA14,CA2,CA3,CA4,CA5A,CA5B,CA6,CA7,CA9
04520Adherens junction3.81e-12ACP1,EGFR,ERBB2,FGFR1,FYN,INSR,MET,PTPN1,PTPN6,PTPRF,SRC,YES1
04151PI3K-Akt signalling pathway6.47e-09CDK4,CDK6,CHRM1,CHRM2,CSF1R,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,FLT1,FLT4,INSR,KDR,KIT,MET,NOS3
04014Ras signalling pathway1.22e-08CSF1R,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,FLT1,FLT4,INSR,KDR,KIT,MET,PLA2G1B,PTPN11
04015Rap1 signalling pathway4.72e-08CSF1R,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,FLT1,FLT4,INSR,KDR,KIT,MET,SRC
04913Ovarian steroidogenesis5.27e-08ALOX5,CYP17A1,CYP19A1,CYP1B1,HSD17B1,HSD17B2,INSR,LDLR
04144Endocytosis1.93e-07CSF1R,EGFR,ERBB4,FGFR2,FGFR3,FGFR4,FLT1,KDR,KIT,LDLR,MET,SRC
00590Arachidonic acid metabolism2.04e-07ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,CYP2C19,PLA2G1B,PTGES
05206MicroRNAs in cancer1.05e-06ABCB1,ABCC1,CDC25A,CDC25B,CDK6,CYP1B1,EGFR,ERBB2,FGFR3,MET
00140Steroid hormone biosynthesis1.44e-06CYP17A1,CYP19A1,CYP1A2,CYP1B1,HSD11B1,HSD17B1,HSD17B2
01100Metabolic pathways2.81e-06AKR1A1,AKR1B1,AKR1B10,ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,AOX1,CYP17A1,CYP19A1,CYP1A2,CYP2C19,CYP51A1,GBA,HMGCR,HSD11B1,HSD17B1,HSD17B2,NOS1,NOS2,NOS3,PLA2G1B,PTGES,XDH
05200Pathways in cancer4.18e-06AR,CDK4,CDK6,CSF1R,EGFR,ERBB2,FGFR1,FGFR2,FGFR3,KIT,MET,MMP2,NOS2
05205Proteoglycans in cancer4.18e-06EGFR,ERBB2,ERBB4,ESR1,FGFR1,KDR,MET,MMP2,PTPN11,PTPN6,SRC
04810Regulation of actin cytoskeleton2.22e-05CHRM1,CHRM2,CHRM4,CHRM5,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,SRC
04020Calcium signalling pathway4e-05CHRM1,CHRM2,CHRM5,EGFR,ERBB2,ERBB4,NOS1,NOS2,NOS3
05219Bladder cancer7.13e-05CDK4,EGFR,ERBB2,FGFR3,MMP2
04976Bile secretion8.95e-05ABCB1,ABCC2,ABCG2,CA2,HMGCR,LDLR
04726Serotonergic synapse0.000115ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,CYP2C19,SLC6A4
00591Linoleic acid metabolism0.000464ALOX15,CYP1A2,CYP2C19,PLA2G1B
04915Estrogen signalling pathway0.000464EGFR,ESR1,ESR2,MMP2,NOS3,SRC
04510Focal adhesion0.000734EGFR,ERBB2,FLT1,FLT4,FYN,KDR,MET,SRC
04066HIF-1 signalling pathway0.000751EGFR,ERBB2,FLT1,INSR,NOS2,NOS3
04080Neuroactive ligand-receptor interaction0.000844ADRA2A,ADRA2B,ADRA2C,CHRM1,CHRM2,CHRM4,CHRM5,
NR3C1,PRSS1
04725Cholinergic synapse0.000851ACHE,CHRM1,CHRM2,CHRM4,CHRM5,FYN
05218Melanoma0.000996CDK4,CDK6,EGFR,FGFR1,MET
05204Chemical carcinogenesis0.0011CYP1A2,CYP1B1,CYP2C19,HSD11B1,MGST1
02010ABC transporters0.00138ABCB1,ABCC1,ABCC2,ABCG2
05215Prostate cancer0.00239AR,EGFR,ERBB2,FGFR1,FGFR2
00232Caffeine metabolism0.00402CYP1A2,XDH
05223Non-small cell lung cancer0.00402CDK4,CDK6,EGFR,ERBB2
05212Pancreatic cancer0.00619CDK4,CDK6,EGFR,ERBB2
00982Drug metabolism - cytochrome P4500.00678AOX1,CYP1A2,CYP2C19,MGST1
05120Epithelial cell signalling in Helicobacter pylori infection0.0074EGFR,MET,PTPN11,SRC
00980Metabolism of xenobiotics by cytochrome P4500.00805CYP1A2,CYP1B1,HSD11B1,MGST1
04917Prolactin signaling pathway0.00873CYP17A1,ESR1,ESR2,SRC
00040Pentose and glucuronate interconversions0.01AKR1A1,AKR1B1,AKR1B10
04010MAPK signalling pathway0.01CDC25B,EGFR,FGFR1,FGFR2,FGFR3,FGFR4,MAPT
04060Cytokine-cytokine receptor interaction0.0119CSF1R,EGFR,FLT1,FLT4,KDR,KIT,MET
00380Tryptophan metabolism0.0151AOX1,CYP1A2,CYP1B1
04012ErbB signalling pathway0.0151EGFR,ERBB2,ERBB4,SRC
04022cGMP-PKG signalling pathway0.0256ADRA2A,ADRA2B,ADRA2C,INSR,NOS3
05202Transcriptional mis-regulation in cancer0.03CSF1R,FLT1,MET,MMP3,MPO
00561Glycolipid metabolism0.0349AKR1A1,AKR1B1,AKR1B10
00330Arginine and proline metabolism0.0397NOS1,NOS2,NOS3
04370VEGF signalling pathway0.0418KDR,NOS3,SRC
04964Proximal tubule bicarbonate reclamation0.0418CA2,CA4
05214Glioma0.0449CDK4,CDK6,EGFR
04110Cell cycle0.0483CDC25A,CDC25B,CDK4,CDK6