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Fig. 7 | BMC Complementary and Alternative Medicine

Fig. 7

From: Clinical evidence-guided network pharmacology analysis reveals a critical contribution of β1-adrenoreceptor upregulation to bradycardia alleviation by Shenxian-Shengmai

Fig. 7

Effects of SXSM on ADRB1 expression in cultured cardiomyocytes. (A) representative images of H9c2 cells with different treatments. (a) untreated control, (b) positive control (isoproterenol, 10 uM), (c) low dose of SXSM (0.5 mg/ml), (d) high dose of SXSM (1 mg/ml). Blue fluorescence represents nucleus stained by Hoechst, and yellow fluorescence represents ADRB1 protein which exists both on cell membrane and in cytoplasm. The expression level of ADRB1 was up-regulated, indicating that SXSM regulated β1-adrenergic signaling pathway activation. (B) Bar graph quantitation of ADRB1 levels in H9c2 cells with different treatments. n≥5, **means p<0.001, ***means p<0.0001 compared with control

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