Fig. 4From: Clinical evidence-guided network pharmacology analysis reveals a critical contribution of β1-adrenoreceptor upregulation to bradycardia alleviation by Shenxian-ShengmaiEffects of SXSM on acetylcholine-induced bradyarrhythmia in isolated rat heart. (A) representative ECG recordings of isolated and perfused rat hearts. Sample speed at 1k/s. Display of recorded results within 30 seconds. (a) untreated blank. (b)After acetylcholine perfusion. (c)After 1mg/ml SXSM perfusion. (B) Quantitation and statistical analysis of heart rate in each treatment group. There was no significant difference between the SXSM and blank groups. (C) Quantitation and statistical analysis of heart rate variability in each group. There was no significant difference between the SXSM and blank groups. Data are presented as mean ± SD (n =6). *P < 0.05Back to article page