Effects of MEDD on inflammatory cytokine expression in IMQ-induced psoriasis. The dorsal skin of mice was treated with Vaseline, IMQ, IMQ and Vh or MEDD for 7 days, and cytokine levels were analyzed the next day. a mRNA levels of pro-inflammatory cytokines, Tnf-α, Ifng, Il6, Il17a, Il22, and Ccl2 in dorsal skin. b IL-17A measurement in each group of mouse serum by ELISA. These results represent the mean ± S.D. of four independent experiments. Statistical analysis was performed using Student’s t-test. * p < 0.05, compared with mice in the IMQ- and vehicle-treated group; ### p < 0.001, compared with Vaseline control mice; IMQ, imiquimod; Vh, Vehicle; MEDD, methanol extract of Dictamnus dasycarpus root bark; N.D, Not detected.