Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum leaves and its effect on lung pathological changes in an ovalbumin-induced rat model of asthma

Table 2 IFN-γ, IL-4, IFN-γ/IL-4 and IgE values in sensitized group treated with three different concentrations of O. basilicum (S + OB)

Groups	IFN-γ (pg/ml)	IL-4 (pg/ml)	IFN-γ/IL-4	IgE (ng/ml)
S + OB 0.75 mg/ml	1.99 ± 0.15	4.99 ± 0.04	0.40 ± 0.03	43.66 ± 0.56
S + OB 1.50 mg/ml	2.39 ± 0.03 ⁺	4.55 ± 0.03 ⁺⁺⁺	0.53 ± 0.01 ⁺⁺	19.49 ± 0.74 ⁺⁺⁺
S + OB 3.00 mg/ml	2.75 ± 0.03 ^{+++ #}	4.27 ± 0.04 ^{+++ ##}	0.64 ± 0.01 ^{+++ ##}	13.70 ± 0.11 ^{+++ ###}

⁺: p < 0.05, ⁺⁺: p < 0.01, ⁺⁺⁺: p < 0.001, comparison with S + OB 0.75 group. ^#: p < 0.05, ^##: p < 0.01, ^###: p < 0.001, comparison between S + OB 3.00 and S + OB 1.50 groups. Values are expressed as mean ± SEM. One-way analysis of variance (ANOVA) with Tukey-Kramer’s post-test was used for statistical comparisons, (in each group, n = 8)

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