Fig. 7
From: Inhibitory effects of ChondroT and its constituent herbs on RANKL-induced osteoclastogenesis
Schematic diagram for ChondroT regulation on osteoclast differentiation and function. RANKL binding to RANK on the surface of osteoclast precursors induces the recruitment of TRAF6, which leads to NF-κB activation and translocation to nucleus, as well as the phosphorylation of MAPKs. Both pathways could be inhibited by ChondroT or its constituent herbs, and subsequently inhibits the osteoclast-specific genes, thus resulting in the reduction of mature osteoclast with potent bone resorptive activity