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Table 3 Effect of MAS 200 on biomarkers of oxidative stress and inflammatory in varicocele-induced male SD rats

From: The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in varicocelized rats

ParameterCTRMAS 200VCVC + MAS 200
MDA (μmole/mg protein)7.37 ± 0.076.26 ± 0.6911.38 ± 0.51*5.46 ± 1.05##
ROS/RNS (nanomole DCF/ mg protein)86.71 ± 10.9183.55 ± 9.68181.84 ± 10.51***67.51 ± 11.88###
SOD level (units/mg protein)8.32 ± 0.267.03 ± 0.634.12 ± 0.30***6.10 ± 0.47#
GPx (nanomoles/min/mg protein)33.44 ± 2.2540.17 ± 3.0223.82 ± 2.19*37.72 ± 1.75##
Catalase (nanomoles/min/mg protein)122.01 ± 8.75138.32 ± 14.5681.81 ± 12.82149.03 ± 8.37##
IL-6 (pg/mg protein)1636.12 ± 111.901779.21 ± 45.163165.71 ± 489.91**1552.65 ± 153.45##
TNF-α (pg/mg protein)962.54 ± 52.38889.23 ± 42.601684.47 ± 94.90***920.37 ± 37.06###
  1. Data are presented in mean ± SEM. The differences were tested by one-way ANOVA followed by Tukey’s post hoc test; n = 10 for each group. *Significant at P < 0.05; ** Significant at P < 0.01; *** Significant at P < 0.001- versus CTR group; #Significant at P < 0.05; ##Significant at P < 0.01; ###Significant at P < 0.001- versus VC group. CTR control, MAS 200 MAS 200 mg/kg p.o., VC varicocele, VC + MAS 200 MAS 200 mg/kg p.o., MDA Malondialdehyde, ROS/RNS reactive oxygen species/reactive nitrogen species, SOD superoxide dismutase, GPx glutathione peroxidase, IL-6 interleukin-6, TNF-α tumor necrosis factor- α, p.o. per oral, ANOVA analysis of variance, SEM standard error of the mean