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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

Fig. 3

Cucurbitacins inhibit nerve growth factor (NGF)-mediated tropomyosin receptor kinase A (TrkA) pathway in PC12 cells. The inhibition of TrkA phosphorylation induced by cucurbitacin B (CuB), CuE, and CuI was assayed in the presence or absence of the indicated cucurbitacin concentrations, and the inhibitor GW441756 as a positive control. (a) CuB inhibited TrkA and downstream Akt phosphorylation in a concentration-dependent manner. (b) CuE inhibited TrkA and downstream Akt phosphorylation in a concentration-dependent manner. (c) CuI inhibited TrkA and downstream Akt phosphorylation in a concentration-dependent manner. The blot shown is representative of at least three experiments

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