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Fig. 2 | BMC Complementary and Alternative Medicine

Fig. 2

From: Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

Fig. 2

Two binding modes of Cucurbitacins in the tropomyosin receptor kinase A (TrkA) binding site. (a) The molecular surface of TrkA colored according to the electrostatic potential. (b) Closer view of the docking model of Cucurbitacins and TrkA. Hydrogen-bonding interactions are shown as orange lines and the hydrogen-bonding interactions of the amino acids stabilize the complex

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