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Fig. 1 | BMC Complementary and Alternative Medicine

Fig. 1

From: Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

Fig. 1

Cucurbitacins inhibit Tropomyosin receptor kinase A (TrkA) kinase activity at the cellular level. (a) Chemical structure of cucurbitacin B (CuB), CuE, and CuI. (b) TrkA activity in the presence or absence of increasing concentrations of CuB, CuE, and CuI. The results are presented as the percentage of kinase activity relative to the control (dimethyl sulfoxide), and the average of at least duplicate reactions, in which similar results were obtained

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