Fig. 5From: Curcumin ameliorates peritoneal fibrosis via inhibition of transforming growth factor-activated kinase 1 (TAK1) pathway in a rat model of peritoneal dialysisEffect of curcumin on the expressions of collagen I in peritoneum of experimental PF model. Peritoneal expression of collagen I presented as staining area (%). Few collagen I were observed in the peritoneum of the control rats (a), but high collagen I expression were found in the PF rats (b). Curcumin at 10 mg/kg (c), 20 mg/kg (d) and 40 mg/kg (e) all markedly reduced the collagen I staining area. f Quantification analysis of the collagen I staining area in the peritoneum (%) in each group. g Quantitative real-time PCR showed the collagen I mRNA expression in the peritoneum of each group. ANOVA was performed and followed with Tukey’s post hoc test. ***P < 0.001 vs. control group; ##P < 0.01, ###P < 0.001 vs. PF groupBack to article page