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Table 4 In vitro effect of lupeol and β-sitosterol-3-O-β-D-glucopyranoside on the proliferation of human cancer cell lines and non-tumorigenic cell line (Vero cells)

From: Anti-inflammatory and cytotoxic activities of the extracts, fractions, and chemical constituents isolated from Luehea ochrophylla Mart

Compounds MDA-MB-231 MCF-7 HCT-116 Vero
IC50 ± SD SI IC50 ± SD SI IC50 ± SD SI IC50 ± SD
Lupeol 60 ± 17.2 0.8 67 ± 22.4 0.8 35.2 ± 13.2 1.5 51 ± 18.2
β-Sitosterol-3-O-β-D-glucopyranoside 33 ± 10.1 0.6 11 ± 5.2 1.9 1.279 ± 0.7 16.4 21 ± 9.9
Cisplatin > 100   > 100   > 100   13.05 ± 0.6
  1. Data are presented as mean ± SD. IC50 50% inhibition of cell growth. SI Selectivity index calculated as follows IC50 (μg/mL) for Vero / IC50 (μg/mL) for tumor cells