The fallacy of enzymatic hydrolysis for the determination of bioactive curcumin in plasma samples as an indication of bioavailability: a comparative study

Table 1 AUC_0-6h ± SEM (ng*h/mL) for human plasma samples from 8 subjects that were assayed with and without enzymatic hydrolysis

NON-HYDROLYZED			HYDROLYZED
Curcumin	Curcumin Glucuronide	Total Curcumin^a	Curcumin	Tetrahydrocurcumin	Total Curcumin^a
0.36 ± 0.71	78.2 ± 20.3	53.9 ± 13.9	486 ± 105	1449 ± 217	1676 ± 179

^aCorrected—curcumin quantity from each form adjusted by molecular weights for each analyte

ISSN: 2662-7671