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Table 1 Cytotoxic concentration 50% (CC50), effective concentration 50% (EC50), and selectivity index (SI) values of the evaluated ethanolic extracts, fractions, and compounds in VERO cells infected with DENV-2/NG

From: In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting

Type of compound Scientific name Family Voucher number Plant part CC50 CE50 SI
Ethanolic extracts Cymbopogon citratos Staf Poaceae JBC 12015 Leaves 155.1 343.1 0.5
Sarcostemma clausum Jacq Asclepiadaceae JBC 2502 Leaves 565.7 458.7 1.2
Diospyros inconstans Jacq Ebenaceae JBC 1438 Bark 727.1 538.6 1.4
Chrysobalanus icaco L Chrysobalanaceae JBC 934 Seeds 550.8 325.8 1.7
Trichilia hirta L Meliaceae JBC 917 Seeds 213.6 62.9 3.4
Croton malambo Karst Euphorbiaceae JBC 12008 Bark 127.3 31.3 4.1
Ambrosia cumanensis Kunt Asteraceae COL 538448 Leaves 112.4 26.7 4.2
Chenopodium ambrosioides L Chenopodiaceae JBC 4005 Leaves 131.6 24.8 5.3
Cavanillesia platanifolia Bonpl Bombacaceae JBC 47576 Almond 252.6 43.5 5.8
Momordica charantia L Cucurbitaceae JBC 793 Seeds 125.3 15.9 7.9
Mammea americana L Calophyllaceae JBC 467 Leaves 440.7 52.3 8.4
Psidium guajava L Myrtaceae JBC 1209 Bark 1000.0 7.8 128.2
Fractions Psidium guajava L HUA 140931 Pg-YP-I-22A 130.5 134.4 1.0
Pg-YP-I-22B 308.9 26.5 11.7
Pg-YP-I-22C 625.7 17.7 35.4
Pg-YP-I-22D 177.9 56.1 3.2
Pg-YP-I-22E 102.2 16.7 6.1
Compounds Pg-YP-I-22C Gallic Acid 543.4 25.8 21.1
Naringin 646.8 47.9 13.5
Quercetin 659.8 19.2 34.3
Catechin 833.3 33.7 24.8
Hesperidin 413.8 225.8 1.8
  1. Group A: No selectivity, SI < 2.0
  2. Group B: Low selectivity, SI ≥ 2.0 and < 5
  3. Group C: Moderate selectivity, SI ≥ 5 and < 10
  4. Group D: High selectivity, SI ≥ 10
  5. • The plants Cymbopogon citratos Staf, Sarcostemma clausum Jacq, Diospyros inconstans Jacq, Chrysobalanus icaco L, Trichilia hirta L and Croton malambo Karst, Chenopodium ambrosioides L, Cavanillesia platanifolia Bonpl, Momordica charantia L, Mammea americana L, Psidium guajava L were identified at the Jardin Botanico de Cartagena (JBC)
  6. • The plant Ambrosia cumanensis Kunt was identified at the Herbarium of the Universidad Nacional de Colombia (COL)
  7. • The plant used to obtain the fractions from Psidium guajava L was identified at the Herbarium of the Universidad de Antioquia (HUA)