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Table 2 Combination Index of Gemcitabine and SN Extracts Combinatorial Treatment at Different Ratios on PDAC

From: The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma

Cell Lines Gema:SN ratio Combination Index (CI) Values at Interaction
ED50 ED75 ED90 Mean ±SD
BxPC3 1:4 0.48 0.60 0.83 0.64 ± 0.18 Synergism
1:2 0.29 0.41 0.59 0.43 ± 0.15 Synergism
1:1 0.26 0.42 0.70 0.46 ± 0.22 Synergism
2:1 0.31 0.45 0.68 0.48 ± 0.19 Synergism
4:1 0.44 0.49 0.55 0.49 ± 0.05 Synergism
SW1990 1:4 0.50 0.39 0.30 0.39 ± 0.10 Synergism
1:2 0.33 0.26 0.21 0.27 ± 0.06 Strong Synergism
1:1 0.31 0.24 0.19 0.24 ± 0.06 Strong Synergism
2:1 0.27 0.27 0.27 0.27 ± 0.00 Strong Synergism
4:1 0.20 0.28 0.38 0.29 ± 0.09 Strong Synergism
AsPC1 1:4 1.12 0.87 0.74 0.91 ± 0.19 Nearly Additive
1:2 0.59 0.42 0.34 0.45 ± 0.13 Synergism
1:1 0.45 0.28 0.21 0.32 ± 0.13 Synergism
2:1 0.34 0.20 0.15 0.23 ± 0.10 Strong Synergism
4:1 0.30 0.17 0.12 0.20 ± 0.09 Strong Synergism
  1. aGem Gemcitabine, SN SN Extracts