The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma

Table 2 Combination Index of Gemcitabine and SN Extracts Combinatorial Treatment at Different Ratios on PDAC

Cell Lines	Gem^a:SN ratio	Combination Index (CI) Values at					Interaction
Cell Lines	Gem^a:SN ratio	ED50	ED75	ED90	Mean	±SD	Interaction
BxPC3	1:4	0.48	0.60	0.83	0.64	± 0.18	Synergism
	1:2	0.29	0.41	0.59	0.43	± 0.15	Synergism
	1:1	0.26	0.42	0.70	0.46	± 0.22	Synergism
	2:1	0.31	0.45	0.68	0.48	± 0.19	Synergism
	4:1	0.44	0.49	0.55	0.49	± 0.05	Synergism
SW1990	1:4	0.50	0.39	0.30	0.39	± 0.10	Synergism
	1:2	0.33	0.26	0.21	0.27	± 0.06	Strong Synergism
	1:1	0.31	0.24	0.19	0.24	± 0.06	Strong Synergism
	2:1	0.27	0.27	0.27	0.27	± 0.00	Strong Synergism
	4:1	0.20	0.28	0.38	0.29	± 0.09	Strong Synergism
AsPC1	1:4	1.12	0.87	0.74	0.91	± 0.19	Nearly Additive
	1:2	0.59	0.42	0.34	0.45	± 0.13	Synergism
	1:1	0.45	0.28	0.21	0.32	± 0.13	Synergism
	2:1	0.34	0.20	0.15	0.23	± 0.10	Strong Synergism
	4:1	0.30	0.17	0.12	0.20	± 0.09	Strong Synergism

ISSN: 2662-7671