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Table 3 In vivo comparison of S. cumini leaves extract, aspirin and control on inhibition of platelet aggregation in rabbits. Agg RAM aggregometer was used to perform this test. Blood was taken in the ratio of 9:1 v/v in trisodium citrate (3.8%)

From: In vivo assessment of anticoagulant and antiplatelet effects of Syzygium cumini leaves extract in rabbits

Groups

Days

Inhibition of platelet aggregation (%)

AA (500 μg/mL)

ADP (20 μmol/L)

Collagen (10 μg/mL)

Epinephrine (300 μmol/L)

Control

30

69.54 ± 8.12

41.54 ± 3.24

20.74 ± 1.54

14.65 ± 0.88

60

76.12 ± 7.58

41.66 ± 3.68

20.65 ± 0.89

14.24 ± 0.97

SCD1

30

65.29 ± 6.21*

36.66 ± 0.54*

20.41 ± 0.75

13.45 ± 1.24

60

57.55 ± 7.08*

37.80 ± 0.87*

17.54 ± 1.12*

13.20 ± 1.54*

SCD2

30

60.89 ± 6.29**

35.37 ± 0.70*

18.80 ± 0.98

13.98 ± 0.95

60

52.06 ± 5.98**

33.65 ± 1.21*

16.99 ± 2.54*

13.00 ± 0.84*

Aspirin

30

43.44 ± 8.45**

30.45 ± 0.98**

12.87 ± 1.23**

12.59 ± 1.05*

60

46.87 ± 8.99**

26.76 ± 1.25**

12.33 ± 1.01**

12.98 ± 0.90*

  1. n = 10, Average values ± SEM;
  2. SCD1: S. cumini dose 1; 150 mg/kg; SCD2: S. cumini dose 2; 500 mg/kg
  3. *p ≤ 0.05 significant as compared to control; **p ≤ 0.005 highly significant as compared to control
  4. AA Arachidonic acid, ADP Adenosine diphosphate