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Table 3 In vivo comparison of S. cumini leaves extract, aspirin and control on inhibition of platelet aggregation in rabbits. Agg RAM aggregometer was used to perform this test. Blood was taken in the ratio of 9:1 v/v in trisodium citrate (3.8%)

From: In vivo assessment of anticoagulant and antiplatelet effects of Syzygium cumini leaves extract in rabbits

Groups Days Inhibition of platelet aggregation (%)
AA (500 μg/mL) ADP (20 μmol/L) Collagen (10 μg/mL) Epinephrine (300 μmol/L)
Control 30 69.54 ± 8.12 41.54 ± 3.24 20.74 ± 1.54 14.65 ± 0.88
60 76.12 ± 7.58 41.66 ± 3.68 20.65 ± 0.89 14.24 ± 0.97
SCD1 30 65.29 ± 6.21* 36.66 ± 0.54* 20.41 ± 0.75 13.45 ± 1.24
60 57.55 ± 7.08* 37.80 ± 0.87* 17.54 ± 1.12* 13.20 ± 1.54*
SCD2 30 60.89 ± 6.29** 35.37 ± 0.70* 18.80 ± 0.98 13.98 ± 0.95
60 52.06 ± 5.98** 33.65 ± 1.21* 16.99 ± 2.54* 13.00 ± 0.84*
Aspirin 30 43.44 ± 8.45** 30.45 ± 0.98** 12.87 ± 1.23** 12.59 ± 1.05*
60 46.87 ± 8.99** 26.76 ± 1.25** 12.33 ± 1.01** 12.98 ± 0.90*
  1. n = 10, Average values ± SEM;
  2. SCD1: S. cumini dose 1; 150 mg/kg; SCD2: S. cumini dose 2; 500 mg/kg
  3. *p ≤ 0.05 significant as compared to control; **p ≤ 0.005 highly significant as compared to control
  4. AA Arachidonic acid, ADP Adenosine diphosphate