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Table 1 In vivo comparison of Syzygium cumini leaves extract, warfarin and control on rabbit’s coagulation parameters. Humaclot duo coagulometer and human reagent kits were used to perform these tests. Clot formation was evaluated by turbidimetric technique

From: In vivo assessment of anticoagulant and antiplatelet effects of Syzygium cumini leaves extract in rabbits

Groups

Days

Parameters

BT (Sec)

TT (Sec)

PT (Sec)

aPTT (Sec)

Fb (mg/dl)

Control

30

180.8 ± 36.82

20.6 ± 3.36

12.7 ± 0.85

14.6 ± 1.57

401.6 ± 24.66

60

170.8 ± 19.38

21.2 ± 2.77

12.3 ± 1.05

14.2 ± 0.92

410.6 ± 17.79

SCD1

30

337.2 ± 11.69**

22.6 ± 2.61

17.4 ± 3.32

19.1 ± 1.69*

331.6 ± 13.72**

60

341.2 ± 7.39**

23.0 ± 2.00

14.22 ± 1.54

17.9 ± 2.10*

320.2 ± 29.12**

SCD2

30

315.0 ± 66.33**

26.8 ± 1.92

24.4 ± 2.30

19.3 ± 3.45*

316.0 ± 23.45**

60

303.0 ± 44.38**

24.8 ± 2.73

17.2 ± 2.19**

17.6 ± 2.07*

326.6 ± 26.26**

Warfarin

335.4 ± 24.60**

31.8 ± 4.97**

64.4 ± 17.21**

30.1 ± 1.30**

303.0 ± 21.54**

  1. n = 10, Average values ± SEM,
  2. *p ≤ 0.05 significant as compared to control, **p ≤ 0.005 highly significant as compared to control
  3. SCD1: S. cumini dose 1; i.e. 150 mg/kg, SCD2: S. cumini dose 2; i.e. 500 mg/kg
  4. BT Bleeding time, TT Thrombin time, PT Prothrombin time, aPTT activated partial thromboplastin time, Fb Fibrinogen level