Skip to main content

Table 1 In vivo comparison of Syzygium cumini leaves extract, warfarin and control on rabbit’s coagulation parameters. Humaclot duo coagulometer and human reagent kits were used to perform these tests. Clot formation was evaluated by turbidimetric technique

From: In vivo assessment of anticoagulant and antiplatelet effects of Syzygium cumini leaves extract in rabbits

Groups Days Parameters
BT (Sec) TT (Sec) PT (Sec) aPTT (Sec) Fb (mg/dl)
Control 30 180.8 ± 36.82 20.6 ± 3.36 12.7 ± 0.85 14.6 ± 1.57 401.6 ± 24.66
60 170.8 ± 19.38 21.2 ± 2.77 12.3 ± 1.05 14.2 ± 0.92 410.6 ± 17.79
SCD1 30 337.2 ± 11.69** 22.6 ± 2.61 17.4 ± 3.32 19.1 ± 1.69* 331.6 ± 13.72**
60 341.2 ± 7.39** 23.0 ± 2.00 14.22 ± 1.54 17.9 ± 2.10* 320.2 ± 29.12**
SCD2 30 315.0 ± 66.33** 26.8 ± 1.92 24.4 ± 2.30 19.3 ± 3.45* 316.0 ± 23.45**
60 303.0 ± 44.38** 24.8 ± 2.73 17.2 ± 2.19** 17.6 ± 2.07* 326.6 ± 26.26**
Warfarin 335.4 ± 24.60** 31.8 ± 4.97** 64.4 ± 17.21** 30.1 ± 1.30** 303.0 ± 21.54**
  1. n = 10, Average values ± SEM,
  2. *p ≤ 0.05 significant as compared to control, **p ≤ 0.005 highly significant as compared to control
  3. SCD1: S. cumini dose 1; i.e. 150 mg/kg, SCD2: S. cumini dose 2; i.e. 500 mg/kg
  4. BT Bleeding time, TT Thrombin time, PT Prothrombin time, aPTT activated partial thromboplastin time, Fb Fibrinogen level