Advertisement
Table 2 Pharmacokinetic parameters of oxyresveratrol alone and in combination with piperine
| Parameters | Intravenous | Oral | ||
|---|---|---|---|---|
| Oxyresveratrol alone (10 mg/kg) | Oxyresveratrol + piperine (10 + 1 mg/kg) | Oxyresveratrol alone (100 mg/kg) | Oxyresveratrol + piperine (100 + 10 mg/kg) | |
| Oxyresveratrol | ||||
| Cmax (μg/L) | N/A | N/A | 977.99 ± 649.59 | 1580.99 ± 674.31* |
| Tmax (h) | N/A | N/A | 2.08 ± 1.11 | 1.30 ± 0.67 |
| AUC0-t (μg.h/L) | 825.60 ± 545.26 | 1455.90 ± 1953.48 | 5133.32 ± 1227.78 | 7837.18 ± 2603.81* |
| AUC0-inf (μg.h/L) | 825.80 ± 545.18 | 1471.00 ± 1945.62 | 5431.21 ± 1022.82 | 9375.27 ± 1974.32* |
| MRT (h) | 1.40 ± 0.29 | 1.60 ± 0.42 | 7.25 ± 4.07 | 11.66 ± 8.11 |
| Vd (L/kg) | 47.30 ± 42.97 | 68.60 ± 60.02 | 105.10 ± 73.82 | 138.10 ± 112.83 |
| CL (L/h/kg) | 16.90 ± 9.30 | 14.60 ± 8.57 | 19.05 ± 4.06 | 11.09 ± 2.52 |
| T1/2 (h) | 1.70 ± 0.77 | 2.80 ± 1.60 | 3.72 ± 1.95 | 8.67 ± 6.55 |
| Relative bioavailability (%) | 100 | 178 | 100 | 173 |
| Oxyresveratrol glucuronide | ||||
| AUC0-t (μg.h/L) | 20,875.50 ± 19,742.93 | 1190.60 ± 231.25 | 10,518.33 ± 6239.13 | 6977.34 ± 811.94 |
| AUC0-inf (μg.h/L) | 20,875.80 ± 19,742.99 | 1640.00 ± 743.29 | 10,993.61 ± 6140.74 | 7491.24 ± 522.99 |
| Ratio of AUCoxyresveratrol glucuronide/AUCoxyresveratrol | 25.28 | 1.11 | 2.02 | 0.80* |
