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Table 5 Effects of BZ formula and its main components timosaponin BII and mangiferin on P450 activity in rat liver microsomes

From: Baihe Zhimu formula attenuates the efficacy of tamoxifen against breast cancer in mice through modulation of CYP450 enzymes

Names CYP450s IC50 (μg/mL)
ZB formula 1A2 93.2 ± 2.1
2D6 45.6 ± 2.6
3A4 74.4 ± 6.2
Timosaponin B II 1A2 >  100
2D6 >  100
3A4 >  100
Mangiferin 1A2 90.6 ± 5.1
2D6 41.3 ± 4.3
3A4 93.8 ± 2.2