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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Baihe Zhimu formula attenuates the efficacy of tamoxifen against breast cancer in mice through modulation of CYP450 enzymes

Fig. 5

Effects of BZ formula and its main components, timosaponin BII and mangiferin, on P450 activity in rat liver microsomes. a Cytotoxicity of BZ formula and its main components on human L02 hepatocytes was measured 48 h after treatment using the MTT test. The effects of b BZ formula, c timosaponin BII, and d mangiferin on P450 activity in rat liver microsomes. After a 1-h incubation, the microsomes were exposed to the indicated concentrations of BZ formula, timosaponin BII, or mangiferin. Results are expressed as the percentage of cell viability compared to the controls (untreated microsomes). Each point represents the mean ± SD of three replicates. * p < 0.05 compared to the vehicle group based on one-way ANOVA

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