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Fig. 2 | BMC Complementary and Alternative Medicine

Fig. 2

From: Baihe Zhimu formula attenuates the efficacy of tamoxifen against breast cancer in mice through modulation of CYP450 enzymes

Fig. 2

BZ formula attenuated the effectiveness of tamoxifen against breast cancer in mice. Nude mice were injected with estrogen receptor-positive (ER+) human breast cancer MCF-7 cells and then treated with 4 mg/kg tamoxifen (TAM) alone or in combination with BZ formula (BZ-L/BZ-H, 2 or 8 g/kg) or paroxetine (PX, 4 mg/kg). The control group was treated with an equal volume of physiological saline. There were five animals per group. a Representative bioluminescent images of tumor-bearing mice. b Normalized bioluminescent signals for mice from each experimental group. * p < 0.05 and ** p < 0.01 compared to the vehicle group based on one-way ANOVA. # p < 0.05 and ## p < 0.01 compared to the tamoxifen group based on one-way ANOVA. c Xenograft tumor growth as measured by volume during treatment. d Comparison of tumor samples excised from vehicle and treatment groups. e Final xenograft tumor weight. * p < 0.05 and ** p < 0.01 compared to the vehicle group based on one-way ANOVA. # p < 0.05 and ## p < 0.01 compared to the tamoxifen group based on one-way ANOVA. f Comparison of tumor suppressor rate. g Changes in body weight of tumor-bearing mice after 8 weeks of treatment with tamoxifen alone or in combination with BZ or paroxetine

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