Fig. 2From: Baihe Zhimu formula attenuates the efficacy of tamoxifen against breast cancer in mice through modulation of CYP450 enzymesBZ formula attenuated the effectiveness of tamoxifen against breast cancer in mice. Nude mice were injected with estrogen receptor-positive (ER+) human breast cancer MCF-7 cells and then treated with 4 mg/kg tamoxifen (TAM) alone or in combination with BZ formula (BZ-L/BZ-H, 2 or 8 g/kg) or paroxetine (PX, 4 mg/kg). The control group was treated with an equal volume of physiological saline. There were five animals per group. a Representative bioluminescent images of tumor-bearing mice. b Normalized bioluminescent signals for mice from each experimental group. * p < 0.05 and ** p < 0.01 compared to the vehicle group based on one-way ANOVA. # p < 0.05 and ## p < 0.01 compared to the tamoxifen group based on one-way ANOVA. c Xenograft tumor growth as measured by volume during treatment. d Comparison of tumor samples excised from vehicle and treatment groups. e Final xenograft tumor weight. * p < 0.05 and ** p < 0.01 compared to the vehicle group based on one-way ANOVA. # p < 0.05 and ## p < 0.01 compared to the tamoxifen group based on one-way ANOVA. f Comparison of tumor suppressor rate. g Changes in body weight of tumor-bearing mice after 8 weeks of treatment with tamoxifen alone or in combination with BZ or paroxetineBack to article page