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Table 2 The distribution and mean scores of histopathological changes due to toxicity in mice liver of each group

From: Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin

Features/ Groups Inflammation Degeneration Necrosis Sinusoidal dilatation Microvesicular steatosis
Distribution (n = 10) Mean score ± S.E.M Distribution (n = 10) Mean score ± S.E.M Distribution (n = 10) Mean score ± S.E.M Distribution (n = 10) Mean score ± S.E.M Distribution (n = 10) Mean score ± S.E.M
I (vehicle control) 10 1.0 ± 0.0 0 0.0 ± 0.0 0 0.0 ± 0.0a 0 0.0 ± 0.0 0 0.0 ± 0.0b
II (carcinogen control) 10 1.8 ± 0.1a 2 0.3 ± 0.2a 0 0.0 ± 0.0a 8 1.2 ± 0.8a 10 1.7 ± 0.2a
III (treatment, annonacin) 10 1.0 ± 0.0 0 0.0 ± 0.0 0 0.0 ± 0.0a 0 0.0 ± 0.0 4 0.4 ± 0.2bc
IV (treatment control) 10 1.0 ± 0.0 0 0.0 ± 0.0 0 0.0 ± 0.0a 0 0.0 ± 0.0 2 0.2 ± 0.1b
V (reference, curcumin) 10 1.2 ± 0.5 0 0.0 ± 0.0 0 0.0 ± 0.0a 0 0.0 ± 0.0 4 0.4 ± 0.2bc
  1. Values expressed as mean ± S.E.M (n = 10). Means between groups that have no superscript in common are significantly different (Tukey’s LSD, p < 0.05)