Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin

Table 2 The distribution and mean scores of histopathological changes due to toxicity in mice liver of each group

Features/ Groups	Inflammation		Degeneration		Necrosis		Sinusoidal dilatation		Microvesicular steatosis
Features/ Groups	Distribution (n = 10)	Mean score ± S.E.M	Distribution (n = 10)	Mean score ± S.E.M	Distribution (n = 10)	Mean score ± S.E.M	Distribution (n = 10)	Mean score ± S.E.M	Distribution (n = 10)	Mean score ± S.E.M
I (vehicle control)	10	1.0 ± 0.0	0	0.0 ± 0.0	0	0.0 ± 0.0^a	0	0.0 ± 0.0	0	0.0 ± 0.0^b
II (carcinogen control)	10	1.8 ± 0.1^a	2	0.3 ± 0.2^a	0	0.0 ± 0.0^a	8	1.2 ± 0.8^a	10	1.7 ± 0.2^a
III (treatment, annonacin)	10	1.0 ± 0.0	0	0.0 ± 0.0	0	0.0 ± 0.0^a	0	0.0 ± 0.0	4	0.4 ± 0.2^bc
IV (treatment control)	10	1.0 ± 0.0	0	0.0 ± 0.0	0	0.0 ± 0.0^a	0	0.0 ± 0.0	2	0.2 ± 0.1^b
V (reference, curcumin)	10	1.2 ± 0.5	0	0.0 ± 0.0	0	0.0 ± 0.0^a	0	0.0 ± 0.0	4	0.4 ± 0.2^bc

Values expressed as mean ± S.E.M (n = 10). Means between groups that have no superscript in common are significantly different (Tukey’s LSD, p < 0.05)

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