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Table 1 Effect of annonacin on the promotion stage of DMBA/TPA-induced mouse skin tumorigenesis after 22 weeks of treatment

From: Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin

Parameter/ Groups

No. of animals

Body weight (g)

Ratio to final body weight

Tumor latency (week)

Tumor incidence (%)

Tumor burden

Tumor volume (mm3)

Tumor regression

Initial

Effective

Initial

Final

Liver

Kidney

I (vehicle control)

10

10

23.8 ± 0.6a

31.7 ± 1.3a

0.05a

0.01a

II (carcinogen control)

10

10

24.0 ± 0.6a

32.4 ± 0.7ab

0.07b

0.02a

7a

100a

2.2 ± 0.4a

7.9 ± 1.7a

0.61 ± 0.3a

III (treatment, annonacin)

10

10

22.6 ± 0.5a

29.6 ± 1.2a

0.05a

0.01a

9b

50b

1.6 ± 0.3a

1.7 ± 0.4b

0.96 ± 0.4a

IV (treatment control)

10

10

23.6 ± 0.6a

35.3 ± 1.0b

0.05a

0.01a

V (reference, curcumin)

10

10

23.4 ± 0.7a

31.7 ± 1.4a

0.05a

0.01a

8ab

70ab

1.8 ± 0.3a

1.9 ± 0.4b

1.3 ± 0.4a

  1. Values expressed as mean ± S.E.M (n = 10). Means between groups that have no superscript in common are significantly different (Tukey’s LSD, p < 0.05)