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Table 1 Effect of annonacin on the promotion stage of DMBA/TPA-induced mouse skin tumorigenesis after 22 weeks of treatment

From: Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin

Parameter/ Groups No. of animals Body weight (g) Ratio to final body weight Tumor latency (week) Tumor incidence (%) Tumor burden Tumor volume (mm3) Tumor regression
Initial Effective Initial Final Liver Kidney
I (vehicle control) 10 10 23.8 ± 0.6a 31.7 ± 1.3a 0.05a 0.01a
II (carcinogen control) 10 10 24.0 ± 0.6a 32.4 ± 0.7ab 0.07b 0.02a 7a 100a 2.2 ± 0.4a 7.9 ± 1.7a 0.61 ± 0.3a
III (treatment, annonacin) 10 10 22.6 ± 0.5a 29.6 ± 1.2a 0.05a 0.01a 9b 50b 1.6 ± 0.3a 1.7 ± 0.4b 0.96 ± 0.4a
IV (treatment control) 10 10 23.6 ± 0.6a 35.3 ± 1.0b 0.05a 0.01a
V (reference, curcumin) 10 10 23.4 ± 0.7a 31.7 ± 1.4a 0.05a 0.01a 8ab 70ab 1.8 ± 0.3a 1.9 ± 0.4b 1.3 ± 0.4a
  1. Values expressed as mean ± S.E.M (n = 10). Means between groups that have no superscript in common are significantly different (Tukey’s LSD, p < 0.05)