Fig. 2
From: Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin
Annonacin showed significant modulation of molecular targets involved in mouse skin tumorigenesis. qRT-PCR and Bio-Plex MAGPIX revealed down-regulation of AKT (a, g), ERK (b, h), p38 (c, i), MTOR (d, j), Src (f, l) and up-regulation of PTEN (e, k) genes and protein respectively in annonacin treated mouse skin tumorigenesis. * (significant up-regulation - values expressed as relative individual gene expressions to vehicle control group). # (significant down-regulation- values expresses as relative individual gene expression to carcinogen control group). Values with different superscripts letter among the groups are statistically significant (p < 0.05). All experiments were performed in triplicate