Table 3 Effect of rice husk extracts on xenobiotic metabolizing enzyme activities in the liver of rats
Enzyme activities (per mg protein) | 5% Tween-80 | White rice husk | Purple rice husk | ||
|---|---|---|---|---|---|
50 mg/kg bw | 500 mg/kg bw | 50 mg/kg bw | 500 mg/kg bw | ||
CYP1A1 (fmol/min) | 15.48 ± 6.66 | 9.49 ± 3.93 | 12.79 ± 6.50 | 9.86 ± 1.57 | 23.69 ± 5.20* |
CYP1A2 (fmol/min) | 13.80 ± 4.45 | 10.49 ± 5.53 | 14.60 ± 8.51 | 12.65 ± 6.15 | 16.22 ± 4.41 |
CYP3A2 (pmol/min) | 16.48 ± 6.42 | 12.77 ± 1.58 | 9.99 ± 2.81* | 9.99 ± 3.22* | 12.60 ± 2.54 |
Cytochrome P450 reductase (× 10− 3 Unit) | 17.13 ± 3.90 | 24.93 ± 5.99 | 25.26 ± 9.98 | 22.15 ± 9.00 | 17.62 ± 8.90 |
Glutathione S-transferase (× 10− 2 Unit) | 41.70 ± 8.67 | 40.82 ± 7.62 | 47.81 ± 8.81 | 43.22 ± 4.03 | 44.49 ± 4.60 |
UDP-glucuronosyltransferase (× 10− 3 Unit) | 31.13 ± 2.79 | 31.04 ± 3.84 | 36.82 ± 10.36 | 26.63 ± 4.54 | 34.60 ± 7.32 |
NAD(P)H-quinone oxidoreductase (× 10− 3 Unit) | 2.68 ± 0.62 | 2.04 ± 0.47 | 2.26 ± 0.95 | 2.21 ± 0.35 | 1.82 ± 0.46* |
Heme oxygenase (nmol/min) | 5.10 ± 0.59 | 4.18 ± 1.56 | 4.38 ± 1.14 | 3.93 ± 0.52 | 5.61 ± 1.28 |