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Table 3 Effect of rice husk extracts on xenobiotic metabolizing enzyme activities in the liver of rats

From: Inhibitory effect of purple rice husk extract on AFB1-induced micronucleus formation in rat liver through modulation of xenobiotic metabolizing enzymes

Enzyme activities (per mg protein) 5% Tween-80 White rice husk Purple rice husk
50 mg/kg bw 500 mg/kg bw 50 mg/kg bw 500 mg/kg bw
CYP1A1 (fmol/min) 15.48 ± 6.66 9.49 ± 3.93 12.79 ± 6.50 9.86 ± 1.57 23.69 ± 5.20*
CYP1A2 (fmol/min) 13.80 ± 4.45 10.49 ± 5.53 14.60 ± 8.51 12.65 ± 6.15 16.22 ± 4.41
CYP3A2 (pmol/min) 16.48 ± 6.42 12.77 ± 1.58 9.99 ± 2.81* 9.99 ± 3.22* 12.60 ± 2.54
Cytochrome P450 reductase (× 10− 3 Unit) 17.13 ± 3.90 24.93 ± 5.99 25.26 ± 9.98 22.15 ± 9.00 17.62 ± 8.90
Glutathione S-transferase (× 10− 2 Unit) 41.70 ± 8.67 40.82 ± 7.62 47.81 ± 8.81 43.22 ± 4.03 44.49 ± 4.60
UDP-glucuronosyltransferase (× 10− 3 Unit) 31.13 ± 2.79 31.04 ± 3.84 36.82 ± 10.36 26.63 ± 4.54 34.60 ± 7.32
NAD(P)H-quinone oxidoreductase (× 10− 3 Unit) 2.68 ± 0.62 2.04 ± 0.47 2.26 ± 0.95 2.21 ± 0.35 1.82 ± 0.46*
Heme oxygenase (nmol/min) 5.10 ± 0.59 4.18 ± 1.56 4.38 ± 1.14 3.93 ± 0.52 5.61 ± 1.28
  1. Values expressed as mean ± SD, n = 6, *Significant difference from 5% Tween-80 (p < 0.05)