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Table 2 Genotoxicity and antigenotoxicity of rice husk extracts in rat liver

From: Inhibitory effect of purple rice husk extract on AFB1-induced micronucleus formation in rat liver through modulation of xenobiotic metabolizing enzymes

Treatments

Number per 1000 hepatocytes

Mitotic index

% Inhibition

MNH

BNH cells

5% Tween-80

2.6 ± 0.8

2.4 ± 0.4

1.0 ± 0.2

–

WRHE 50 mg/kg bw

2.8 ± 1.3

2.3 ± 0.5

1.0 ± 0.4

–

WRHE 500 mg/kg bw

2.8 ± 0.9

2.1 ± 0.4

0.7 ± 0.2

–

PRHE 50 mg/kg bw

3.3 ± 0.2

1.9 ± 0.2

0.8 ± 0.3

–

PRHE 500 mg/kg bw

3.0 ± 0.9

2.2 ± 0.3

0.9 ± 0.2

–

AFB1 + 5% Tween-80

9.7 ± 2.7*

4.4 ± 0.5*

3.0 ± 0.6*

–

AFB1 + WRHE 50 mg/kg bw

7.2 ± 1.4

3.6 ± 0.1

2.4 ± 0.3

26.0

AFB1 + WRHE 500 mg/kg bw

6.8 ± 0.9

4.3 ± 0.6

2.6 ± 0.5

30.0

AFB1 + PRHE 50 mg/kg bw

5.6 ± 1.9#

4.1 ± 0.3

2.4 ± 0.1

42.3

AFB1 + PRHE 500 mg/kg bw

5.4 ± 1.8#

4.0 ± 0.5

2.3 ± 0.3

44.7

  1. Values expressed as mean ± SD, n = 6
  2. *Significant difference from 5% Tween-80 (p < 0.05), #Significant difference from AFB1 + 5% Tween 80 (p < 0.05)
  3. MNH micronucleated hepatocytes, BNH binucleated hepatocytes, AFB1 Aflatoxin B1,
  4. WRHE white rice husk extract, PRHE purple rice husk extract