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Table 2 Genotoxicity and antigenotoxicity of rice husk extracts in rat liver

From: Inhibitory effect of purple rice husk extract on AFB1-induced micronucleus formation in rat liver through modulation of xenobiotic metabolizing enzymes

Treatments Number per 1000 hepatocytes Mitotic index % Inhibition
MNH BNH cells
5% Tween-80 2.6 ± 0.8 2.4 ± 0.4 1.0 ± 0.2
WRHE 50 mg/kg bw 2.8 ± 1.3 2.3 ± 0.5 1.0 ± 0.4
WRHE 500 mg/kg bw 2.8 ± 0.9 2.1 ± 0.4 0.7 ± 0.2
PRHE 50 mg/kg bw 3.3 ± 0.2 1.9 ± 0.2 0.8 ± 0.3
PRHE 500 mg/kg bw 3.0 ± 0.9 2.2 ± 0.3 0.9 ± 0.2
AFB1 + 5% Tween-80 9.7 ± 2.7* 4.4 ± 0.5* 3.0 ± 0.6*
AFB1 + WRHE 50 mg/kg bw 7.2 ± 1.4 3.6 ± 0.1 2.4 ± 0.3 26.0
AFB1 + WRHE 500 mg/kg bw 6.8 ± 0.9 4.3 ± 0.6 2.6 ± 0.5 30.0
AFB1 + PRHE 50 mg/kg bw 5.6 ± 1.9# 4.1 ± 0.3 2.4 ± 0.1 42.3
AFB1 + PRHE 500 mg/kg bw 5.4 ± 1.8# 4.0 ± 0.5 2.3 ± 0.3 44.7
  1. Values expressed as mean ± SD, n = 6
  2. *Significant difference from 5% Tween-80 (p < 0.05), #Significant difference from AFB1 + 5% Tween 80 (p < 0.05)
  3. MNH micronucleated hepatocytes, BNH binucleated hepatocytes, AFB1 Aflatoxin B1,
  4. WRHE white rice husk extract, PRHE purple rice husk extract