Treatments | Number per 1000 hepatocytes | Mitotic index | % Inhibition | |
---|---|---|---|---|
MNH | BNH cells | |||
5% Tween-80 | 2.6 ± 0.8 | 2.4 ± 0.4 | 1.0 ± 0.2 | – |
WRHE 50 mg/kg bw | 2.8 ± 1.3 | 2.3 ± 0.5 | 1.0 ± 0.4 | – |
WRHE 500 mg/kg bw | 2.8 ± 0.9 | 2.1 ± 0.4 | 0.7 ± 0.2 | – |
PRHE 50 mg/kg bw | 3.3 ± 0.2 | 1.9 ± 0.2 | 0.8 ± 0.3 | – |
PRHE 500 mg/kg bw | 3.0 ± 0.9 | 2.2 ± 0.3 | 0.9 ± 0.2 | – |
AFB1 + 5% Tween-80 | 9.7 ± 2.7* | 4.4 ± 0.5* | 3.0 ± 0.6* | – |
AFB1 + WRHE 50 mg/kg bw | 7.2 ± 1.4 | 3.6 ± 0.1 | 2.4 ± 0.3 | 26.0 |
AFB1 + WRHE 500 mg/kg bw | 6.8 ± 0.9 | 4.3 ± 0.6 | 2.6 ± 0.5 | 30.0 |
AFB1 + PRHE 50 mg/kg bw | 5.6 ± 1.9# | 4.1 ± 0.3 | 2.4 ± 0.1 | 42.3 |
AFB1 + PRHE 500 mg/kg bw | 5.4 ± 1.8# | 4.0 ± 0.5 | 2.3 ± 0.3 | 44.7 |