|
Treatments
|
Number per 1000 hepatocytes
|
Mitotic index
|
% Inhibition
|
|---|
|
MNH
|
BNH cells
|
|---|
|
5% Tween-80
|
2.6 ± 0.8
|
2.4 ± 0.4
|
1.0 ± 0.2
|
–
|
|
WRHE 50 mg/kg bw
|
2.8 ± 1.3
|
2.3 ± 0.5
|
1.0 ± 0.4
|
–
|
|
WRHE 500 mg/kg bw
|
2.8 ± 0.9
|
2.1 ± 0.4
|
0.7 ± 0.2
|
–
|
|
PRHE 50 mg/kg bw
|
3.3 ± 0.2
|
1.9 ± 0.2
|
0.8 ± 0.3
|
–
|
|
PRHE 500 mg/kg bw
|
3.0 ± 0.9
|
2.2 ± 0.3
|
0.9 ± 0.2
|
–
|
|
AFB1 + 5% Tween-80
|
9.7 ± 2.7*
|
4.4 ± 0.5*
|
3.0 ± 0.6*
|
–
|
|
AFB1 + WRHE 50 mg/kg bw
|
7.2 ± 1.4
|
3.6 ± 0.1
|
2.4 ± 0.3
|
26.0
|
|
AFB1 + WRHE 500 mg/kg bw
|
6.8 ± 0.9
|
4.3 ± 0.6
|
2.6 ± 0.5
|
30.0
|
|
AFB1 + PRHE 50 mg/kg bw
|
5.6 ± 1.9#
|
4.1 ± 0.3
|
2.4 ± 0.1
|
42.3
|
|
AFB1 + PRHE 500 mg/kg bw
|
5.4 ± 1.8#
|
4.0 ± 0.5
|
2.3 ± 0.3
|
44.7
|
- Values expressed as mean ± SD, n = 6
- *Significant difference from 5% Tween-80 (p < 0.05), #Significant difference from AFB1 + 5% Tween 80 (p < 0.05)
- MNH micronucleated hepatocytes, BNH binucleated hepatocytes, AFB1 Aflatoxin B1,
- WRHE white rice husk extract, PRHE purple rice husk extract
