Fig. 1

Schematic of the treatment schedule. Adult male Kunming mice (6 weeks old) underwent adapted feeding for 7 days. Except in the CON group, all of the mice were ip injected with 100 mg/kg bw STZ (dissolved in an ice-cold 0.1 mol/L sodium citrate buffer) once. DM mice (fasting blood glucose concentrations higher than 11.1 mmol/L) were randomly divided into five groups after 3 days of modeling: diabetes mellitus group (DM), metformin-treated group (MET), and CTP (CTP-L, CTP-M and CTP-H) group. All of the mice were dosed by gavage once daily for 28 consecutive days