From: Intramuscular autologous blood therapy - a systematic review of controlled trials
Authors | Indication | Sample size | Design | Duration of treatment | Frequency and dosage | Outcome: doctor’s statement p = … in favor to patient’s statement | Comment |
---|---|---|---|---|---|---|---|
Abdallah et al. [14] | Chronic autoreactive urticaria | 30 ASST+ (15 AWB, 15 AS) | RCT: AWB vs. AS, not blinded | 8 weeks | 1x/w; AWB: 1st injection 2.5 ml, following 5 ml; AS: 2 ml every time | AWB: p < 0.01 (weeks 8 + 12) AS: p < 0.01 (weeks 8 + 12) No statistical difference between treatments |  |
Hensler, Gündling et al. [15] | Treatment of Common Cold | 114 (58 AWB, 56 Placebo) | RCT: AWB vs. Placebo double-blinded | 1 week | 3x/w 2 ml | No statistical difference |  |
Jobst, Altiner et al. [2] | prevention of recurring respiratory tract infections | 75 (38 AWB, 37 Engystol®) | RCT: AWB vs. Engystol®, not blinded | 5 weeks | 2x/w 3 ml | No statistical difference between AWB and Engystol® |  |
Kocatürk et al. [16] | Urticaria | 88 (ASST+ 59: 20 AWB, 20 AS, 19 Placebo; ASST- 29: 9 AWB, 10 AS, 10 Placebo) | RCT: AWB vs. AS vs. Placebo, single-blinded | 10 weeks | 1x/w; 1st injection 2.5 ml, following 5 ml | No statistical difference |  |
Min et al. [17] | Chronic Urticaria | 157 (52 AWB, TCM (Chinese Herbs) + Western Medicine, 53 Western Medicine, 52 TCM) | Controlled trial: AWB + TCM + Western Medicine vs. TCM vs. Western Medicine, not randomized, not blinded | 24 days | Every 3 days (total of 8 injections) 5 ml AWB + 1 ml lidocaine + 4 ml H2O, each side 5 ml | Treatment group (AWB + TCM + Western Medicine) more effective than the other groups (p < 0.05) |  |
Pittler, Ernst et al. [3] | Atopic Dermatitis | 30 (15 AWB, 15 Placebo) | RCT: AWB vs. Placebo, double-blinded | 5 weeks | 1x/w; 1–2 – 3 – 2 – 1 ml | SASSAD score: week 5 P = 0.001 week 9 P < 0.001 patient’s statement: no statistical difference |  |
Schirmer, Fritz, Jäckel [18] | Spondylitis ankylosans | 100 (51 AWB + Formica, 49 Placebo) + training scheme (both groups) | RCT: AWB + Formica vs. Placebo double-blinded | 4 weeks | 2x/w 1 ml AWB + 1 ml Formica rufa 6x | No statistical difference | Trial effected in rehabilitation facility |
Staubach, Onnen et al. [19] | Chronic Urticaria | 48 (29 ASST+: 13 AWB, 16 Placebo, 19 ASST-: 10 AWB, 9 Placebo) | RCT: AWB vs. Placebo, single-blinded | 8 weeks | 1x/w; 1st injection 2.5 ml, following 5 ml | ASST+ patients: AWB UAS −41%, p < 0.05, wheals duration + size −46%/−48%, p < 0.05, erythema −56%, p < 0.05, DLQI week8 + 70%, p < 0.005, week12 + 66%, p < 0.05, antihistamines −52%, p < 0.05; Placebo UAS −18%; ASST- patients: AWB UAS −21%, Placebo UAS −11% |  |