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Table 2 Results

From: Intramuscular autologous blood therapy - a systematic review of controlled trials

Authors Indication Sample size Design Duration of treatment Frequency and dosage Outcome: doctor’s statement p = … in favor to patient’s statement Comment
Abdallah et al. [14] Chronic autoreactive urticaria 30 ASST+ (15 AWB, 15 AS) RCT: AWB vs. AS, not blinded 8 weeks 1x/w; AWB: 1st injection 2.5 ml, following 5 ml;
AS: 2 ml every time
AWB: p < 0.01 (weeks 8 + 12)
AS: p < 0.01 (weeks 8 + 12)
No statistical difference between treatments
 
Hensler, Gündling et al. [15] Treatment of Common Cold 114 (58 AWB, 56 Placebo) RCT: AWB vs. Placebo
double-blinded
1 week 3x/w 2 ml No statistical difference  
Jobst, Altiner et al. [2] prevention of recurring respiratory tract infections 75 (38 AWB, 37 Engystol®) RCT: AWB vs. Engystol®, not blinded 5 weeks 2x/w 3 ml No statistical difference between AWB and Engystol®  
Kocatürk et al. [16] Urticaria 88 (ASST+ 59: 20 AWB, 20 AS, 19 Placebo; ASST- 29: 9 AWB, 10 AS, 10 Placebo) RCT: AWB vs. AS vs. Placebo, single-blinded 10 weeks 1x/w; 1st injection 2.5 ml, following 5 ml No statistical difference  
Min et al. [17] Chronic Urticaria 157 (52 AWB, TCM (Chinese Herbs) + Western Medicine,
53 Western Medicine,
52 TCM)
Controlled trial: AWB + TCM + Western Medicine vs. TCM vs. Western Medicine, not randomized, not blinded 24 days Every 3 days (total of 8 injections)
5 ml AWB + 1 ml lidocaine + 4 ml H2O, each side 5 ml
Treatment group (AWB + TCM + Western Medicine) more effective than the other groups (p < 0.05)  
Pittler, Ernst et al. [3] Atopic Dermatitis 30 (15 AWB, 15 Placebo) RCT: AWB vs. Placebo, double-blinded 5 weeks 1x/w; 1–2 – 3 – 2 – 1 ml SASSAD score: week 5 P = 0.001
week 9 P < 0.001
patient’s statement: no statistical difference
 
Schirmer, Fritz, Jäckel [18] Spondylitis ankylosans 100 (51 AWB + Formica, 49 Placebo)
+ training scheme (both groups)
RCT: AWB + Formica vs. Placebo
double-blinded
4 weeks 2x/w 1 ml AWB + 1 ml Formica rufa 6x No statistical difference Trial effected in rehabilitation facility
Staubach, Onnen et al. [19] Chronic Urticaria 48 (29 ASST+: 13 AWB, 16 Placebo, 19 ASST-: 10 AWB, 9 Placebo) RCT: AWB vs. Placebo, single-blinded 8 weeks 1x/w; 1st injection 2.5 ml, following 5 ml ASST+ patients:
AWB UAS −41%,
p < 0.05, wheals duration + size −46%/−48%, p < 0.05, erythema −56%, p < 0.05, DLQI week8 + 70%, p < 0.005, week12 + 66%, p < 0.05, antihistamines −52%, p < 0.05; Placebo UAS −18%;
ASST- patients:
AWB UAS −21%,
Placebo UAS −11%