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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation

Fig. 4

ASH-WEX restores BDNF–TrkB signaling proteins (a) Representative immunoblots of the TrkB, pAkt, Bcl-xL in hippocampus (left panel) and pyriform cortex (right panel) regions of brain amidst the four group of animals (n = 4–5/group). (b, c) histograms presenting relative densitometric analysis in (b) hippocampus and (c) pyriform cortex regions amidst the different treatment groups plotted as Mean ± SEM (taking control group as 100%). α-Tubulin was used for the normalization of protein expression. (d, e) Histograms depicting relative mRNA levels of BDNF, TrkB, PLCγ, IP3R, PI3K, Akt, and Bcl-xL in (d) hippocampus and (e) pyriform cortex regions amidst the four groups (n = 4–5/group) plotted as Mean ± SEM from three independent experiments. *p ≤ 0.05 control versus ASH-WEX alone and LPS + ASH-WEX groups. +p ≤ 0.05 control versus LPS alone group. #p ≤ 0.05 LPS alone versus LPS + ASH-WEX group (one-way ANOVA with Holm-Sidak post hoc test)

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