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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation

Fig. 3

ASH-WEX normalizes the expression of various synaptic plasticity markers (a) Representative western blots of the PSA-NCAM, NCAM and GAP43 in hippocampus (left panel) and pyriform cortex (right panel) regions of brain amidst the four group of animals (n = 4–5/group). (b, c) histograms depicting relative densitometric analysis amidst the different treatment groups from (b) hippocampus and (c) pyriform cortex regions of brain plotted as Mean ± SEM (taking control group as 100%). (Expression of NCAM was calculated as cumulative of both 180 kDa and 140 kDa bands) (d) Representative immunoblots of MAP2, Calcineurin and CAMKIIα in hippocampus (left panel) and pyriform cortex (right panel) regions of brain amidst the four group of animals (n = 4–5/group). (e, f) Histograms depicting relative densitometric analysis amidst the different treatment groups in (e) hippocampus and (f) pyriform cortex regions plotted as Mean ± SEM (taking control group as 100%). α-Tubulin was used for the normalization of protein expression. *p ≤ 0.05 control versus ASH-WEX alone and LPS + ASH-WEX groups. +p ≤ 0.05 control versus LPS alone group. #p ≤ 0.05 LPS alone versus LPS + ASH-WEX group (one-way ANOVA with Holm-Sidak post hoc test)

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