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Table 4 Inhibitory activities of the mushroom HAEs and ASEs during screening, attachment and penetration assays

From: Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study

  Screening Attachment Penetration
IC50 (μg/ml) SI IC50 (μg/ml) SI IC50 (μg/ml) SI
P. giganteus HAE 344.8 ± 35.4** 12.4 ± 2.2** 1731 ± 160** 2.5 ± 0.3**
L. rhinocerotis HAE 485.9 ± 69.5** 7.4 ± 0.4**
S. commune HAE 312.9 ± 14.1** 13.7 ± 4.8* 943.1 ± 70.4** 4.5 ± 0.4**
H. erinaceus HAE 680.6 ± 79.3** 7.8 ± 2.6* 2080.2 ± 252.7** 2.5 ± 0.3**
P. giganteus ASE 637.9 ± 40.3** 15.7 ± 1** 872 ± 63.2** 11.5 ± 0.9** 315.4 ± 52.4** 32.3 ± 5.7**
L. rhinocerotis ASE 399.2 ± 18.9** 7.6 ± 0.6** 261.2 ± 38.3** 11.9 ± 1.7** 226.3 ± 157.1 17.5 ± 8.7
S. commune ASE 424.9 ± 76.6** 24.1 ± 4.4** 1245.8 ± 73.7** 8.1 ± 0.5** 279.3 ± 27.3** 36 ± 3.7**
H. erinaceus ASE 574.4 ± 83.4** 17.7 ± 2.7** 327.6 ± 29.2** 30.7 ± 2.9** 278.7 ± 87* 38.2 ± 11.4*
Ribavirin 80.7 ± 1.8** 10.9 ± 2.8** 205 ± 15.2** 4.3 ± 0.5**
  1. The anti-DENV2 activities of the mushroom extracts in Vero cells were evaluated in three different assays: simultaneous, attachment and penetration by the plaque reduction assay. The IC50 value, the concentration of extract required to inhibit 50% of virus growth compared with the virus control group, was calculated from the dose response curve of three independent experiments using probit analysis (n = 3). The selectivity index (SI) was calculated as the CC50/IC50. Statistical differences compared to the untreated virus control group are noted with asterisk (*P < 0.05) or (**p < 0.01)