Butyrlycholine esterase inhibitory activity and effects of extracts (fruit, bark and leaf) from Zanthoxylum armatum DC in gut, airways and vascular smooth muscles

Table 1 Antidiarrheal activity of Z. armatum fruit, bark, leaves crude extracts, and verapamil

Group	Dose	Total number of feces in 4 h	Total number of wet feces in 4 h	Protection (%)
Saline control	10 ml/kg	30 ± 0.63	1.0 ± 0.16	94.45 ± 5.55
Castor oil	10 ml/kg	21 ± 0.22	20 ± 0.21	5.5 ± 5.5
Zf Extract	100 mg/kg	18 ± 0.39	10 ± 0.33	45.55 ± 5.21
Zf Extract	300 mg/kg	24 ± 0.22	8 ± 0.16	65 ± 5.42^a
Zf Extract	1000 mg/kg	25 ± 0.37	6 ± 0.3	76.11 ± 5.58^b
Zb Extract	100 mg/kg	18 ± 0.33	13 ± 0.23	5.5 ± 5.5
Zb Extract	300 mg/kg	17 ± 0.20	8 ± 0.27	23.67 ± 8.18
Zb Extract	1000 mg/kg	26 ± 0.39	8 ± 0.29	52.75 ± 5.11^a
Zl Extract	100 mg/kg	15 ± 0.40	12 ± 0.40	19.43 ± 9.04
Zl Extract	300 mg/kg	14 ± 0.18	7 ± 0.19	50 ± 4.3^a
Zl Extract	1000 mg/kg	24 ± 0.40	9 ± 0.31	63.34 ± 1.49^b
Verapamil	3 mg/kg	50 ± 0.21	14 ± 0.21	71.99 ± 2.4^a
Verapamil	10 mg/kg	33.0 ± 0.21	2 ± 0.34	94.84 ± 3.27^b
Verapamil	30 mg/kg	29 ± 0.41	1.0 ± 0.16	96.67 ± 3.33^c

Mean ± SEM; n = 6, ^ap < 0.05; ^bp < 0.01; ^cp<,0.001 vs control, Dunnet’s t-test

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