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Table 1 Antidiarrheal activity of Z. armatum fruit, bark, leaves crude extracts, and verapamil

From: Butyrlycholine esterase inhibitory activity and effects of extracts (fruit, bark and leaf) from Zanthoxylum armatum DC in gut, airways and vascular smooth muscles

Group Dose Total number of feces in 4 h Total number of wet feces in 4 h Protection (%)
Saline control 10 ml/kg 30 ± 0.63 1.0 ± 0.16 94.45 ± 5.55
Castor oil 10 ml/kg 21 ± 0.22 20 ± 0.21 5.5 ± 5.5
Zf Extract 100 mg/kg 18 ± 0.39 10 ± 0.33 45.55 ± 5.21
Zf Extract 300 mg/kg 24 ± 0.22 8 ± 0.16 65 ± 5.42a
Zf Extract 1000 mg/kg 25 ± 0.37 6 ± 0.3 76.11 ± 5.58b
Zb Extract 100 mg/kg 18 ± 0.33 13 ± 0.23 5.5 ± 5.5
Zb Extract 300 mg/kg 17 ± 0.20 8 ± 0.27 23.67 ± 8.18
Zb Extract 1000 mg/kg 26 ± 0.39 8 ± 0.29 52.75 ± 5.11a
Zl Extract 100 mg/kg 15 ± 0.40 12 ± 0.40 19.43 ± 9.04
Zl Extract 300 mg/kg 14 ± 0.18 7 ± 0.19 50 ± 4.3a
Zl Extract 1000 mg/kg 24 ± 0.40 9 ± 0.31 63.34 ± 1.49b
Verapamil 3 mg/kg 50 ± 0.21 14 ± 0.21 71.99 ± 2.4a
Verapamil 10 mg/kg 33.0 ± 0.21 2 ± 0.34 94.84 ± 3.27b
Verapamil 30 mg/kg 29 ± 0.41 1.0 ± 0.16 96.67 ± 3.33c
  1. Mean ± SEM; n = 6, ap < 0.05; bp < 0.01; cp<,0.001 vs control, Dunnet’s t-test