Table 1 Cytotoxic effects of Apiole derivatives (AP-02, 04, 05) upon various human breast (MDA-MB-231, ZR75), lung (A549, PE089), liver (Hep G2, Hep 3B), and colon (COLO 205, HT 29) cancer cells
Organ | Tissue Sources | Cell lines | Time (h) | Mean IC50 ± SD (μM) | |||
|---|---|---|---|---|---|---|---|
Apiole | AP-02 | AP-04 | AP-05 | ||||
Breast | Human breast cancer | MDA-MB-231 | 48 | NA | 227.27 ± 2.90 | NA | 380.20 ± 3.28 |
Human breast cancer | ZR-75 | 48 | NA | NA | NA | NA | |
Human breast epithelial | MCF-10A | 48 | NA | 138.19 ± 2.31 | NA | 158.66 ± 1.92 | |
Lung | Human lung cancer | A549 | 48 | NA | 348.97 ± 2.62 | NA | 486.03 ± 4.27 |
Human lung cancer | PE089 | 48 | NA | 191.79 ± 2.30 | NA | 300.66 ± 2.48 | |
Human lung fibroblast | HEL299 | 48 | NA | 50.95 ± 0.46 | 241.44 ± 3.90 | 91.85 ± 1.25 | |
Liver | Human liver cancer | HepG2 | 48 | NA | 206.03 ± 7.37 | 526.81 ± 0.81 | 225.33 ± 4.37 |
Human liver cancer | Hep3B | 48 | NA | 122.92 ± 2.59 | NA | 322.50 ± 1.47 | |
Rat liver epithelial | Clone 9 | 48 | NA | 43.67 ± 0.95 | 513.89 ± 16.47 | 374.41 ± 3.95 | |
Mouse liver epithelial | BNL cl.2 | 48 | NA | 153.58 ± 0.54 | NA | 522.62 ± 3.55 | |
Colon | Human colon cancer | Colon 205 | 48 | NA | 16.57 ± 0.39 | 604.34 ± 19.80 | 133.77 ± 1.32 |
Human colon cancer | HT-29 | 48 | NA | 38.45 ± 1.85 | NA | 67.65 ± 0.06 | |
Human colon epithelail | FHC | 48 | NA | 263.76 ± 6.31 | 263.76 ± 4.63 | 336.47 ± 6.03 | |