Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Cytotoxic effects of Apiole derivatives (AP-02, 04, 05) upon various human breast (MDA-MB-231, ZR75), lung (A549, PE089), liver (Hep G2, Hep 3B), and colon (COLO 205, HT 29) cancer cells

From: Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells

OrganTissue SourcesCell linesTime (h)Mean IC50 ± SD (μM)
ApioleAP-02AP-04AP-05
BreastHuman breast cancerMDA-MB-23148NA227.27 ± 2.90NA380.20 ± 3.28
Human breast cancerZR-7548NANANANA
Human breast epithelialMCF-10A48NA138.19 ± 2.31NA158.66 ± 1.92
LungHuman lung cancerA54948NA348.97 ± 2.62NA486.03 ± 4.27
Human lung cancerPE08948NA191.79 ± 2.30NA300.66 ± 2.48
Human lung fibroblastHEL29948NA50.95 ± 0.46241.44 ± 3.9091.85 ± 1.25
LiverHuman liver cancerHepG248NA206.03 ± 7.37526.81 ± 0.81225.33 ± 4.37
Human liver cancerHep3B48NA122.92 ± 2.59NA322.50 ± 1.47
Rat liver epithelialClone 948NA43.67 ± 0.95513.89 ± 16.47374.41 ± 3.95
Mouse liver epithelialBNL cl.248NA153.58 ± 0.54NA522.62 ± 3.55
ColonHuman colon cancerColon 20548NA16.57 ± 0.39604.34 ± 19.80133.77 ± 1.32
Human colon cancerHT-2948NA38.45 ± 1.85NA67.65 ± 0.06
Human colon epithelailFHC48NA263.76 ± 6.31263.76 ± 4.63336.47 ± 6.03
  1. NA: IC 50 non-available, * p < 0.05; ** p < 0.01