Fig. 6

Growth of COLO 205 tumor xenografts in nude mice is suppressed in response to AP-02 treatment. Athymic nude mice were injected with COLO 205 cells into interscapular subcutaneous tissue. Once tumor volume reached approximately 200 mm³, animals were treated with 1 or 5 mg/kg AP-02 or PBS intraperitoneally three times per week for 6 weeks. a Average tumor volume of PBS-treated (circle, n = 5) versus AP-02-treated (n = 5) nude mice. b Body weight was measured each week during the experiment. Five samples were analyzed in each group, and values represent the means ± SE. Comparisons were subjected to Student’s t-test. ^* Significant difference at p < 0.05