Fig. 3

Cytotoxicity of apiole and its derivatives (AP-02, AP-04 and AP-05) in human cancer cells and normal cells. In this study, human breast (MDA-MB-231, ZR75), lung (A549, PE089), liver (Hep G2, Hep 3B), and colon (COLO 205, HT 29) cancer cells, as well as normal human breast (MCF 10A), lung (HEL 299), liver (BNL-CL2, Clone 9), and colon (FHC) cells were treated with compounds (apiole, Ap-02, Ap-04, and Ap-05; 4.5–600 μM) for 24 h, and IC50 values were determined