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Table 4 Serum chemistry analysis after administration of Myelophil for 13 weeks

From: Acute and repeated toxicological study of Myelophil, an ethanol extract of a mixture of Astragali Radix and Salviae Miltiorrhizae Radix, in beagle dogs

MYP (mg/kg, Number) Male Female
0 (5) 312.5 (3) 625 (3) 1250 (5) 0 (5) 312.5 (3) 625 (3) 1250 (5)
AST (IU/L) 38.4 ± 9.6 48.0 ± 7.2 42.3 ± 12.1 47.8 ± 6.8 40.6 ± 5.1 44.0 ± 2.0 47.3 ± 16.4 44.0 ± 6.0
ALT (IU/L) 40.0 ± 10.2 37.7 ± 9.1 31.3 ± 6.0 47.8 ± 19.8 36.8 ± 5.7 37.0 ± 5.6 40.0 ± 14.8 40.4 ± 10.4
ALP (IU/L) 334.8 ± 97.7 494.0 ± 103.5 330.3 ± 116.6 345.2 ± 60.2 336.8 ± 120.0 219.3 ± 50.5 295.0 ± 10.4 289.4 ± 79.7
BUN (mg/dL) 16.6 ± 2.4 17.4 ± 2.6 15.0 ± 2.3 14.3 ± 1.6 17.4 ± 4.8 17.0 ± 1.7 14.4 ± 2.7 14.4 ± 2.4
Creatinine (mg/dL) 0.72 ± 0.03 0.66 ± 0.11 0.77 ± 0.06 0.82 ± 0.10 0.72 ± 0.13 0.63 ± 0.03 0.75 ± 0.05 0.72 ± 0.08
Glucose (mg/dL) 89.8 ± 7.3 79.3 ± 3.8 84.3 ± 7.8 84.4 ± 9.5 86.6 ± 4.0 84.7 ± 3.1 92.0 ± 3.0 86.4 ± 9.6
Total cholesterol (mg/dL) 184.0 ± 35.2 169.7 ± 27.2 151.7 ± 19.7 170.6 ± 37.3 160.0 ± 28.9 165.7 ± 34.6 150.3 ± 3.2 162.6 ± 32.2
Total protein (g/dL) 5.5 ± 0.4 5.6 ± 0.2 5.6 ± 0.4 5.9 ± 0.3 5.8 ± 0.3 5.7 ± 0.4 5.8 ± 0.2 5.8 ± 0.4
CPK (U/L) 242.6 ± 45.3 372.0 ± 152.2 307.0 ± 77.2 369.2 ± 122.9 256.0 ± 56.2 319.0 ± 79.7 362.3 ± 249.4 256.0 ± 75.6
Albumin (g/dL) 2.6 ± 0.2 2.7 ± 0.1 2.6 ± 0.1 2.8 ± 0.1 2.7 ± 0.3 2.7 ± 0.3 2.9 ± 0.2 2.9 ± 0.2
Total bilirubin (mg/dL) 0.04 ± 0.01 0.06 ± 0.02 0.04 ± 0.02 0.06 ± 0.03 0.07 ± 0.02 0.05 ± 0.02 0.06 ± 0.03 0.07 ± 0.02
A/G ratio 0.89 ± 0.19 0.94 ± 0.02 0.87 ± 0.14 0.88 ± 0.07 0.88 ± 0.07 0.93 ± 0.09 0.98 ± 0.05 0.99 ± 0.04
Triglyceride (mg/dL) 24.4 ± 3.6 44.0 ± 17.8 23.0 ± 4.0 30.4 ± 9.8 28.0 ± 2.9 28.0 ± 4.4 31.3 ± 6.1 30.2 ± 9.3
Calcium (mg/dL) 10.3 ± 0.4 10.4 ± 0.4 10.2 ± 0.5 10.6 ± 0.5 10.3 ± 0.4 10.2 ± 0.5 10.3 ± 0.4 10.2 ± 0.6
Inorganic phosphorus (mg/dL) 6.0 ± 0.7 6.0 ± 0.1 5.7 ± 0.7 5.8 ± 0.6 5.2 ± 0.4 4.9 ± 0.3 5.1 ± 1.3 4.8 ± 0.3
Chloride (mmol/L) 112.4 ± 1.5 112.3 ± 0.6 110.7 ± 1.5 111.0 ± 2.0 109.8 ± 10.3 107.0 ± 1.7* 109.7 ± 1.2 108.6 ± 0.9*
Sodium (mmol/L) 149.2 ± 1.3 148.0 ± 0.0 148.0 ± 1.0 148.0 ± 2.4 146.4 ± 1.5 144.0 ± 1.0* 148.0 ± 1.7 145.8 ± 0.8*
Potassium (mmol/L) 5.3 ± 0.3 5.4 ± 0.2 5.4 ± 0.2 5.7 ± 0.2 5.0 ± 0.4 5.3 ± 0.2 5.3 ± 0.2 5.1 ± 0.2
  1. After the administration of MYP for 13 weeks, the serum chemistry was analyzed and compared to the control group
  2. The data were expressed as the means ± sd
  3. AST Aspartate aminotransferase, ALT Alanine aminotransferase, ALP Alkaline phosphatase, BUN Blood urea nitrogen, CPK Creatine phosphokinase, A/G ratio Albumin globulin ratio
  4. *A statistical significance was considered if P < 0.05 compared with the vehicle control